1787: CRISPR-Cas Transposase Part II
|Name:||1787: CRISPR-Cas Transposase Part II|
|Expired:||01/23/2020 - 23:00|
|Description:||Fold this transposase protein from a CRISPR-Cas complex! This puzzle presents the second half of the transposase protein, as a follow-up to Puzzle 1784: CRISPR-Cas Transposase Part I.
CRISPR-Cas is a mixed complex of RNA and proteins, which work together to make a very precise cut in a cell's DNA. Scientists recently discovered a variant of CRISPR-Cas that coopts a new protein called a transposase. In addition to cutting DNA, the transposase also allows precise insertion of new material into a target DNA strand. This new variant could lead to more efficient gene editing with CRISPR-Cas! New cryoEM experiments have shed some light on the transposase structure, which was previously unknown.
We're asking Foldit players to help solve how this transposase protein folds! The transposase is a large 400-residue protein, so this puzzle only includes half of the full protein sequence. Later, we'll post additional puzzles with cryoEM density for the transposase protein!
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