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1776: Symmetric Tetramer Design: H-bond Networks
Status: Closed

Summary

Name: 1776: Symmetric Tetramer Design: H-bond Networks
Status: Closed
Created: 12/20/2019
Points: 100
Expired: 12/27/2019 - 23:00
Difficulty: Intermediate
Description: Design a symmetric tetramer, with 4 identical chains that assemble together. The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.
Categories: Design, Overall, Symmetry

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Comments

bkoep's picture
User offline. Last seen 20 hours 36 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Core Existence: Monomer (max +2800)
Ensures that at least 19 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network:
Rewards networks that comprise at least two H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Joined: 06/24/2008
Groups: Void Crushers
Core Existence: Monomer

I think the real max Core Existence: Monomer is 1900.

vakobo's picture
User offline. Last seen 4 weeks 5 days ago. Offline
Joined: 06/05/2008
Groups: Russian team
H-Bond Network limit

I have 8 H-Bond networks (two symmetric rings) with 2 H-Bonds each (100% polars satisfied) but only 6 of them are credited with 400 bonus points. Thereby insteed of 3200 i've got only 2400 bonus points. Is there limit of 12 H-Bonds?

bkoep's picture
User offline. Last seen 20 hours 36 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Yes, that's right!

Bonuses are only awarded for maximum 12 H-bonds in networks. Sorry if that wasn't clear in the Objectives description!

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