puzzle picture
1773: Symmetric Trimer Design: H-Bond Networks
Status: Closed


2Anthropic Dreams22,74574
3Beta Folders22,69854
5Go Science22,50027
6Void Crushers22,42918
7Russian team22,11112
8L'Alliance Francophone21,7438
9Marvin's bunch20,1575
10Team Schleswig-Holstein19,1713
11Hun-Magyar Csapat18,8272
12Hold My Beer16,8661
15Italiani Al Lavoro11,2721
16Trinity Biology10,1771
18Dutch Power Cows01

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bkoep's picture
User offline. Last seen 1 day 5 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Core Existence: Monomer (max +2800)
Ensures that at least 28 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network:
Rewards networks that comprise at least two H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

spvincent's picture
User offline. Last seen 5 hours 2 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
Unsatisfied polars

I believe this point has cropped up before, but it would be nice if there was some way of determining what polar bonds are unsatisfied in an H-bond network.

bkoep's picture
User offline. Last seen 1 day 5 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
You're right!

This is the most important aspect of H-bond networks! We're working on better detection of unsatisfied polar atoms already; we'll make sure that these atoms are clearly indicated, as well.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons