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1769: Poly-Proline Helix Design: Round 2
Status: Closed

Summary

Name: 1769: Poly-Proline Helix Design: Round 2
Status: Closed
Created: 12/04/2019
Points: 100
Expired: 12/12/2019 - 23:00
Difficulty: Intermediate
Description: This is the second puzzle in our poly-proline helix design series! This is an 80 residue protein with a 12-residue long frozen poly-proline helix, and designable residues on either side. Just like in Round 1, it will be necessary to satisfy the exposed oxygens on the helix backbone to ensure that the protein stays folded! Globular structures with a hydrophobic core will have the best chance of folding in the real world.

Incorporating poly-proline helices into Foldit will help us design and make proteins with this new element! We are continuing to analyze your designs and improve the game to facilitate work with poly-proline helices.
Categories: Design, Overall

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neilpg628's picture
User offline. Last seen 3 hours 55 min ago. Offline
Joined: 08/01/2019
Groups: None
Objectives

Residue Count (max +100)
Penalizes a residue count above 80 by 20 Foldit points per additional residue.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons