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1763: Poly-Proline Helix Design: Round 1
Status: Closed

Soloists

RankPlayerGroupScorePoints
126alwen 38 222 Anthropic Dreams5,2041
127Hollinas 68 1139 Go Science5,2041
128 bkoep 93 886  5,2041
129domwas 93 2641  5,2041


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Joined: 03/30/2013
Groups: Go Science
poly pro helices

If we are designing collagen-like structures, don't we need hydroxyproline as an amino acid?

see wikipedia
https://en.wikipedia.org/wiki/Hydroxyproline
and
Gorres, Kelly L.; Raines, Ronald T. (April 2010). "Prolyl 4-hydroxylase". Critical Reviews in Biochemistry and Molecular Biology. 45 (2): 106–124.

neilpg628's picture
User offline. Last seen 1 day 4 hours ago. Offline
Joined: 08/01/2019
Groups: Foldit Staff
Hydroxyproline

Collagen happens to contain hydroxyproline (a non-canonical amino acid), but poly-proline helices (and proteins that incorporate them) do not need to contain this residue. Currently Foldit works best with the 20 encoded amino acids, so we try to design puzzles with only these residues.

frood66's picture
User offline. Last seen 8 hours 52 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
no blueprint? - let alone the

no blueprint? - let alone the above.

bkoep's picture
User offline. Last seen 20 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Whoops!

Sorry, that was an oversight! We will be sure to include the Blueprint in future puzzles!

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