Joined: 03/30/2013
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poly pro helices

If we are designing collagen-like structures, don't we need hydroxyproline as an amino acid?

see wikipedia
Gorres, Kelly L.; Raines, Ronald T. (April 2010). "Prolyl 4-hydroxylase". Critical Reviews in Biochemistry and Molecular Biology. 45 (2): 106–124.

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Collagen happens to contain hydroxyproline (a non-canonical amino acid), but poly-proline helices (and proteins that incorporate them) do not need to contain this residue. Currently Foldit works best with the 20 encoded amino acids, so we try to design puzzles with only these residues.

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no blueprint? - let alone the

no blueprint? - let alone the above.

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Sorry, that was an oversight! We will be sure to include the Blueprint in future puzzles!

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