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1763: Poly-Proline Helix Design: Round 1
Status: Closed

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Joined: 03/30/2013
Groups: Go Science
poly pro helices

If we are designing collagen-like structures, don't we need hydroxyproline as an amino acid?

see wikipedia
https://en.wikipedia.org/wiki/Hydroxyproline
and
Gorres, Kelly L.; Raines, Ronald T. (April 2010). "Prolyl 4-hydroxylase". Critical Reviews in Biochemistry and Molecular Biology. 45 (2): 106–124.

neilpg628's picture
User offline. Last seen 2 days 22 hours ago. Offline
Joined: 08/01/2019
Groups: Foldit Staff
Hydroxyproline

Collagen happens to contain hydroxyproline (a non-canonical amino acid), but poly-proline helices (and proteins that incorporate them) do not need to contain this residue. Currently Foldit works best with the 20 encoded amino acids, so we try to design puzzles with only these residues.

frood66's picture
User offline. Last seen 2 days 18 hours ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
no blueprint? - let alone the

no blueprint? - let alone the above.

bkoep's picture
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Joined: 11/15/2012
Groups: Foldit Staff
Whoops!

Sorry, that was an oversight! We will be sure to include the Blueprint in future puzzles!

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