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1760b: Unsolved De-novo Freestyle 157: Symmetric Trimer
Status: Closed


Name: 1760b: Unsolved De-novo Freestyle 157: Symmetric Trimer
Status: Closed
Created: 11/14/2019
Points: 100
Expired: 11/21/2019 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle replaces Puzzle 1760, which was mistakenly posted with the wrong sequence.

This is a follow-up to Puzzle 1757: De-novo Freestyle 157, now with C3 symmetry. This protein was originally designed by a Foldit player as a symmetric trimer. In Puzzle 1757, we challenged the Foldit community to try and predict how the design might fold as a single, monomeric chain. Now we want to see if Foldit players can predict how the protein might fold and bind to itself with C3 symmetry. Players may load in solutions from Puzzle 1757. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

Categories: Overall, Prediction, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons