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1758: Symmetric Trimer Design: H-Bond Networks
Status: Closed
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Summary
| Name: |
1758: Symmetric Trimer Design: H-Bond Networks |
| Status: |
Closed |
| Created: |
11/11/2019 |
| Points: |
100 |
| Expired: |
11/18/2019 - 23:00 |
| Difficulty: |
Intermediate |
| Description: |
H-bond Networks are back! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks. There a few other objectives in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions! |
| Categories: | Design, Overall, Symmetry |
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Core Existence: Monomer (max
+1600+2100)Ensures that at least 21 residues are buried in the core of the monomer unit.
Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.
H-bond Network: Rewards networks that comprise at least two H-bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a h-bond).
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA,
SER, THRin helices.Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.