puzzle picture
1742: IL-7R Binder Redesign: Round 19
Status: Closed

Summary

Name: 1742: IL-7R Binder Redesign: Round 19
Status: Closed
Created: 10/07/2019
Points: 100
Expired: 10/11/2019 - 23:00
Difficulty: Intermediate
Description: Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues flanking the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and/or sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the 19th puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Go Science11,343100
2Contenders11,24576
3Gargleblasters11,24056
4Anthropic Dreams11,21441
5Beta Folders11,13229

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1Bletchley Park 15 30 Contenders11,245100
2Enzyme 134 419 Gargleblasters11,24095
3johnmitch 172 14  11,22989
4ZeroLeak7 38 6 Go Science11,21784
5dcrwheeler 172 8  11,20979


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Comments

bkoep's picture
User offline. Last seen 12 hours 39 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +300)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +100)
Penalizes extra residues inserted beyond 110, at a cost of 20 points per residue. Players may use up to 115 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons