puzzle picture
1730: IL-7R Binder Redesign: Round 13
Status: Closed

Summary

Name: 1730: IL-7R Binder Redesign: Round 13
Status: Closed
Created: 09/13/2019
Points: 100
Expired: 09/17/2019 - 23:00
Difficulty: Intermediate
Description: Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues flanking the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and/or sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the 13th puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Go Science11,458100
2Contenders11,43571
3Gargleblasters11,40149
4Anthropic Dreams11,34733
5Marvin's bunch11,28022

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Comments

Joined: 06/24/2008
Groups: Void Crushers
Bad Residues

It would help if we knew How many bad residues are built into the puzzle so we didn't have waste time trying to find any bad residues that need to be corrected.

bkoep's picture
User offline. Last seen 21 hours 24 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives details

We didn't post the details for the Objectives in this puzzle, sorry for the oversight! See the comment below.

bkoep's picture
User offline. Last seen 21 hours 24 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +300)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +100)
Penalizes extra residues inserted beyond 110, at a cost of 20 points per residue. Players may use up to 115 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons