puzzle picture
1728: IL-7R Binder Redesign: Round 12
Status: Closed

Summary

Name: 1728: IL-7R Binder Redesign: Round 12
Status: Closed
Created: 09/09/2019
Points: 100
Expired: 09/13/2019 - 23:00
Difficulty: Intermediate
Description: Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues between the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the 12th puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! The binding helices in this puzzle are the same as in Round 11, but with with the designable region between the helices instead of at their termini. Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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1Beta Folders11,888100
2Gargleblasters11,73871
3Go Science11,72149
4Contenders11,60933
5Anthropic Dreams11,53422

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Comments

spvincent's picture
User offline. Last seen 30 min 28 sec ago. Offline
Joined: 12/07/2007
Groups: Contenders
This puzzle isn't showing up

This puzzle isn't showing up in the game.

LociOiling's picture
User offline. Last seen 5 hours 45 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
no objectives details

The official details about the objectives for this puzzle are missing. Unofficially, here are the objectives from the previous round, which seem to be the same:

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +100)
Penalizes extra residues inserted beyond 110, at a cost of 20 points per residue. Players may use up to 115 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons