puzzle picture
1719: IL-7R Binder Redesign: Round 8
Status: Closed

Summary

Name: 1719: IL-7R Binder Redesign: Round 8
Status: Closed
Created: 08/23/2019
Points: 100
Expired: 08/28/2019 - 23:00
Difficulty: Intermediate
Description: Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues between the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the eigth puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! The binding helices in this puzzle are the same as in Round 7, but with with the designable region between the helices instead of at their termini. Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Go Science11,669100
2Contenders11,66068
3Beta Folders11,60044
4Anthropic Dreams11,57627
5Gargleblasters11,49416

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 19 hours 52 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +400)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275 +100)
Penalizes extra residues inserted beyond 110, at a cost of 55 20 points per residue. Players may use up to 115 residues in total.

Joined: 06/24/2008
Groups: Void Crushers
Residue Count

I have 11o so I should get 275 but I am getting 100.

bkoep's picture
User offline. Last seen 19 hours 52 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives typo

Sorry! There was a typo in the comment above with details about Objectives. The puzzle is scoring correctly.

In this puzzle, each added residue incurs a penalty of 20 points, and the maximum bonus for the Residue Count Objective is 100 points.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons