Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.
SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.
Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.
maybe 55 points for extra residues is a bit excessive. would like to try something longer and more elegant especially on the transition from the 81-99 helix
That penalty was calibrated from monomer design puzzles; it might make sense to ease up on the penalty for these IL-7R Binder puzzles.
The next Round 6 puzzle will continue to use the 55 point penalty, but we'll do some analysis and maybe make some adjustments in future rounds.