puzzle picture
1713: IL-7R Binder Redesign: Round 5
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams11,597100
2Beta Folders11,55965
3Go Science11,49941
4Gargleblasters11,49224
5Contenders11,46714
6Marvin's bunch11,4527
7L'Alliance Francophone11,3574
8Void Crushers11,2252
9Russian team11,1471
10Hold My Beer10,8311
11BOINC@Poland10,7821
12Hun-Magyar Csapat10,7521
13The Daydreamers10,6191


Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 3 hours 17 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.

Joined: 10/30/2012
Groups: Beta Folders
extra residues

maybe 55 points for extra residues is a bit excessive. would like to try something longer and more elegant especially on the transition from the 81-99 helix

bkoep's picture
User offline. Last seen 3 hours 17 min ago. Offline
Joined: 11/15/2012
Groups: None
Good to know!

That penalty was calibrated from monomer design puzzles; it might make sense to ease up on the penalty for these IL-7R Binder puzzles.

The next Round 6 puzzle will continue to use the 55 point penalty, but we'll do some analysis and maybe make some adjustments in future rounds.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons