puzzle picture
1713: IL-7R Binder Redesign: Round 5
Status: Closed

Summary

Name: 1713: IL-7R Binder Redesign: Round 5
Status: Closed
Created: 08/12/2019
Points: 100
Expired: 08/17/2019 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle was mistakenly set to close on August 19. The puzzle close date has been reset to August 17, at 23:00, to keep the number of open puzzles at a reasonable level.

Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues flanking the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and/or sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the fifth puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams11,597100
2Beta Folders11,55965
3Go Science11,49941
4Gargleblasters11,49224
5Contenders11,46714

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1Waya 6 9 Anthropic Dreams11,591100
2Galaxie 1 2 Anthropic Dreams11,57095
3johnmitch 76 6  11,55990
4fiendish_ghoul 76 11  11,55085
5retiredmichael 16 4 Beta Folders11,54080


Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 2 days 20 hours ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.

Joined: 10/30/2012
Groups: Beta Folders
extra residues

maybe 55 points for extra residues is a bit excessive. would like to try something longer and more elegant especially on the transition from the 81-99 helix

bkoep's picture
User offline. Last seen 2 days 20 hours ago. Offline
Joined: 11/15/2012
Groups: None
Good to know!

That penalty was calibrated from monomer design puzzles; it might make sense to ease up on the penalty for these IL-7R Binder puzzles.

The next Round 6 puzzle will continue to use the 55 point penalty, but we'll do some analysis and maybe make some adjustments in future rounds.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons