puzzle picture
1713: IL-7R Binder Redesign: Round 5
Status: Closed


Name: 1713: IL-7R Binder Redesign: Round 5
Status: Closed
Created: 08/12/2019
Points: 100
Expired: 08/17/2019 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle was mistakenly set to close on August 19. The puzzle close date has been reset to August 17, at 23:00, to keep the number of open puzzles at a reasonable level.

Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues flanking the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and/or sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the fifth puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

1Anthropic Dreams11,597100
2Beta Folders11,55965
3Go Science11,49941

Top Evolvers

Top Soloists

Need this puzzle? Log in to download.  


bkoep's picture
User offline. Last seen 18 hours 11 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.

Joined: 10/30/2012
Groups: Beta Folders
extra residues

maybe 55 points for extra residues is a bit excessive. would like to try something longer and more elegant especially on the transition from the 81-99 helix

bkoep's picture
User offline. Last seen 18 hours 11 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Good to know!

That penalty was calibrated from monomer design puzzles; it might make sense to ease up on the penalty for these IL-7R Binder puzzles.

The next Round 6 puzzle will continue to use the 55 point penalty, but we'll do some analysis and maybe make some adjustments in future rounds.

Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Other Games: Mozak
Only search fold.it
Recommend Foldit
User login
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons