puzzle picture
1708: IL-7R Binder Redesign: Round 3
Status: Closed

Summary

Name: 1708: IL-7R Binder Redesign: Round 3
Status: Closed
Created: 08/03/2019
Points: 100
Expired: 08/07/2019 - 23:00
Difficulty: Intermediate
Description: Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues flanking the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and/or sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the third puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams11,095100
2Contenders11,03060
3Gargleblasters10,97233
4Go Science10,96517
5Beta Folders10,9068

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1Galaxie 2 3 Anthropic Dreams11,095100
2crpainter 82 22 Contenders11,03095
3Waya 9 11 Anthropic Dreams11,00590
4johnmitch 82 9  10,97285
5silent gene 4 4 Go Science10,95280


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Comments

bkoep's picture
User offline. Last seen 39 min 17 sec ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons