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1704: IL-7R Binder Redesign: Round 1
Status: Closed

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bkoep's picture
User offline. Last seen 57 min 10 sec ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +250)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.

NinjaGreg's picture
User offline. Last seen 15 hours 35 min ago. Offline
Joined: 05/21/2010
Groups: Go Science
You start with two extra segments

If you look at the objectives when you first start, you'll see that there are two extra segments over the limit of 110. This will deduct 110 points from your score from the beginning. You can delete these two should you desire to.

NinjaGreg's picture
User offline. Last seen 15 hours 35 min ago. Offline
Joined: 05/21/2010
Groups: Go Science
You also start with 5 invalid residues noted

These are located on the target, and a frozen so you can't change them, but they do not detract from your score.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons