puzzle picture
1704: IL-7R Binder Redesign: Round 1
Status: Closed

Groups

RankGroupScorePoints
1Contenders11,227100
2Anthropic Dreams10,96765
3Go Science10,94941
4Beta Folders10,90224
5Gargleblasters10,77414
6L'Alliance Francophone10,6507
7Marvin's bunch10,6374
8Hun-Magyar Csapat10,5812
9Russian team10,5731
10Hold My Beer10,5101
11Void Crushers10,4991
12Trinity Biology10,1741
13Team South Africa10,0391


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Comments

bkoep's picture
User offline. Last seen 3 hours 33 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +250)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +275)
Penalizes extra residues inserted beyond 110, at a cost of 55 points per residue. Players may use up to 115 residues in total.

NinjaGreg's picture
User offline. Last seen 6 hours 35 min ago. Offline
Joined: 05/21/2010
Groups: Go Science
You start with two extra segments

If you look at the objectives when you first start, you'll see that there are two extra segments over the limit of 110. This will deduct 110 points from your score from the beginning. You can delete these two should you desire to.

NinjaGreg's picture
User offline. Last seen 6 hours 35 min ago. Offline
Joined: 05/21/2010
Groups: Go Science
You also start with 5 invalid residues noted

These are located on the target, and a frozen so you can't change them, but they do not detract from your score.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons