puzzle picture
1701: Cubane FeS Binder Design: Round 2
Status: Closed

Summary

Name: 1701: Cubane FeS Binder Design: Round 2
Status: Closed
Created: 07/19/2019
Points: 100
Expired: 07/26/2019 - 23:00
Difficulty: Intermediate
Description: Design a protein for electron transfer! See the blog for more details!

We're asking Foldit players to design a protein that can bind a cubane type iron-sulfur cluster! In this puzzle, players start with a short loop that contains three cysteine residues bound to the iron-sulfur cluster. The loop and the cluster are frozen in place, but players may fold up the residues on either side of the loop. The final protein will need to include the frozen loop, but should still be well-folded with a large core. This protein is set up identically to Puzzle 1688, although players will not be able to load solutions from the previous puzzle. A recent blog post discusses the results from the first puzzle, and stresses the importance of burying the cluster and minimizing the residues that form loops. See the puzzle comments for Objective details. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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RankGroupScorePoints
1Anthropic Dreams12,894100
2Contenders12,77071
3Beta Folders12,77049
4Go Science12,72533
5Gargleblasters12,71822

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Comments

bkoep's picture
User offline. Last seen 2 days 18 hours ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the core of the protein.

SS Design (max +500)
Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 66, at a cost of 55 points per residue. Players may use up to 76 residues in total.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons