puzzle picture
1698: Medium Monomer Design
Status: Closed

Summary

Name: 1698: Medium Monomer Design
Status: Closed
Created: 07/12/2019
Points: 100
Expired: 07/19/2019 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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RankGroupScorePoints
1Beta Folders13,449100
2Anthropic Dreams13,40971
3Gargleblasters13,38549
4Go Science13,35533
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RankPlayerGroupScorePoints
1LociOiling 2 1 Beta Folders13,447100
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3Waya 7 9 Anthropic Dreams13,39891
4anthion 41 17 Gargleblasters13,38587
5Phyx 20 12 Go Science13,35083


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Comments

bkoep's picture
User offline. Last seen 3 hours 10 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +825)
Penalizes extra residues inserted beyond the starting 75, at a cost of 55 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons