1683: Integrin Antagonist Design: Round 4
|Name:||1683: Integrin Antagonist Design: Round 4|
|Expired:||06/19/2019 - 23:00|
|Description:||Help design a protein for cancer treatment!
Integrins are cell adhesion proteins that are normally inactive on the surface of cells. Once activated by a binding partner, integrins can induce changes in cell cycle, growth factor signaling pathways, cytoskeletal organization, and movement. In some types of cancer, integrins are involved in promoting tumor metastasis and cancer blood vessel formation. We'd like to design an integrin antagonist, which can block regular binding partners and keep integrin in the inactive state!
Integrin is a very large protein, and this puzzle includes only the binding portion of integrin. The integrin backbone is completely frozen, but some sidechains on the surface are allowed to move. Foldit players start with 6 loop residues already placed in the binding pocket; these residues are frozen in place and cannot move, but players have complete freedom to fold and design 65 residues flanking the frozen loop.
In this puzzle, we'd like Foldit players to focus on designing a compact protein with a significant core, so we've added a Core Existence objective with a large bonus value. We think successful antagonists will also need to make at least one other major contact with the integrin surface. Because of some small differences with the previous Round 3 puzzle, players will not be able to load in previous work. See the puzzle comments for objective details. Let’s give cancer a good fight!
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