puzzle picture
1681: Symmetric Trimer Design: 80 Residues
Status: Closed

Groups

RankGroupScorePoints
1Gargleblasters24,744100
2Go Science24,51263
3Void Crushers24,20337
4Beta Folders24,15621
5Marvin's bunch24,14711
6Anthropic Dreams24,1375
7Contenders23,9772
8L'Alliance Francophone23,3281
9Russian team23,3071
10Hun-Magyar Csapat22,2841
11Hold My Beer22,0161
12Extraterrestrials 2.014,9011


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bkoep's picture
User offline. Last seen 17 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Core Existence: Monomer (max +2400)
Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +4200)
Ensures that at least 84 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

Bautho's picture
User offline. Last seen 5 days 22 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
It is always a pity...

It is always a pity when you are not able to delete residues at one end and stick them to the other end of the protein :(

bkoep's picture
User offline. Last seen 17 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
We hear you!

This is a long-standing complaint, and we hope to correct it soon!

For obscure reasons, it is slightly more complicated to implement this for symmetry puzzles (insertions and deletions are more straightforward in the monomer design puzzles). But there are ways around this, and it's on our to-do list!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons