puzzle picture
1678: Extra Large Monomer Design
Status: Closed

Summary

Name: 1678: Extra Large Monomer Design
Status: Closed
Created: 05/22/2019
Points: 100
Expired: 05/31/2019 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 3 hours 30 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1375)
Penalizes extra residues inserted beyond the starting 95, at a cost of 55 points per residue. Players may use up to 120 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

LociOiling's picture
User offline. Last seen 1 hour 30 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons