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1665: Symmetric Dimer Design: 70 Residues
Status: Closed

Summary

Name: 1665: Symmetric Dimer Design: 70 Residues
Status: Closed
Created: 04/22/2019
Points: 100
Expired: 04/29/2019 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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RankGroupScorePoints
1Beta Folders20,966100
2Gargleblasters20,88373
3Go Science20,74852
4Anthropic Dreams20,72036
5Void Crushers20,36624

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Comments

bkoep's picture
User offline. Last seen 18 hours 45 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2300)
Ensures that at least 46 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

grogar7's picture
User offline. Last seen 11 hours 43 min ago. Offline
Joined: 10/03/2011
Ideal Loops filter is not present

Do the devs want to repost or leave it as is?

bkoep's picture
User offline. Last seen 18 hours 45 min ago. Offline
Joined: 11/15/2012
Groups: None
Sorry for the oversight!

Thanks for pointing this out! That was an error in the Objectives description. The puzzle will stay!

jeff101's picture
User offline. Last seen 20 min 38 sec ago. Offline
Joined: 04/20/2012
Groups: Go Science
Puzzle 1665 images

Puzzle 1665 images have been posted at:
https://foldit.fandom.com/wiki/Puzzle_1665

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons