1664: Integrin Antagonist Binder Design: Round 2
|Name:||1664: Integrin Antagonist Binder Design: Round 2|
|Expired:||04/26/2019 - 23:00|
|Description:||Help design a protein binder for cancer therapy!
Integrins are cell adhesion receptors that are normally inactive on the surface of cells. Once activated by a ligand, integrins can induce changes in cell cycle, growth factor signaling pathways, cytoskeletal organization, and movement. Recently, integrins have emerged as a key target in anti-cancer therapy as integrins are involved in promoting tumor metastasis and cancer blood vessel formation. Integrin antagonists have already proven successful in halting invasion and migration of tumors.
Round 2: We’re asking Foldit players to help design a complete antagonist of integrin Avb3 once more. Given the crash reports and the size of the protein in the first round, we've simplified the target to reduce wiggle and shake time. The backbone and side-chains of the target integrin are also frozen. The core RGD motif of the binder is frozen, but Foldit players can design the remaining residues into a well-folded protein!
This puzzle also includes a Core Existence Objective; designs with a significant core will receive a score bonus. See puzzle comments for Objective details.
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