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1662: Medium Monomer Design
Status: Closed

Summary

Name: 1662: Medium Monomer Design
Status: Closed
Created: 04/15/2019
Points: 100
Expired: 04/22/2019 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 57 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1000 +825)
Penalizes extra residues inserted beyond the starting 75, at a cost of 55 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

Joined: 03/08/2012
Groups: None
Objectives V2

Residue Count: nominal residues count of 75 gives +825 points
(0 over limit of 75)

bkoep's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 11/15/2012
Groups: None
You're right!

That was an error in the Objective description, and has been corrected.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons