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1655: Symmetric Tetramer Design: 65 Residues
Status: Closed


Name: 1655: Symmetric Tetramer Design: 65 Residues
Status: Closed
Created: 03/28/2019
Points: 0
Expired: 04/04/2019 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle was closed early due to a faulty Objective, and reposted as Puzzle 1655b. Players may load their current work into the reposted puzzle.

This symmetric design puzzle has C4 symmetry, with four symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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1Russian team16,1120
2Anthropic Dreams11,1960

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1cbwest 170 133  17,6760
2vakobo 170 16997 Russian team16,1120
3rabamino12358 170 198  12,0990
4robgee 5 12 Anthropic Dreams11,1960
5TastyMunchies 170 42  9,8300

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bkoep's picture
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Joined: 11/15/2012
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Core Existence: Monomer (max +1800)
Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2200)
Ensures that at least 88 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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