I can see a few issues with the design of this puzzle. First, it would appear that segments 69 and 70 are locked, so if 70 is part of a helix one can't use the "5" key to get an ideal helix. Second. the band between the two sheet segments (91-92, 99-100) can't be clicked on to create a solidified sheet. Third, the score seems to be hugely negative at all times. Fourth, having the fixed portion in the middle of two loops really constrains what can be done. Just sayin'.
This puzzle has been closed and reposted as Puzzle 1650b.
I'm sorry to say we can't address all of these issues. The cutpoints are permanent, and cannot be closed. This is important for keeping the loop frozen in place.
The constraint of having the fixed portion in the middle of the chain is what makes this puzzle especially challenging! Currently, we don't have great automated methods for "growing" a protein design out of a fixed loop like this. We think Foldit players might be better-suited to tackle this kind of problem.
this is broken