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1650: B7-2 Binder Design: Stabilize the Loop!
Status: Closed

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NinjaGreg's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 05/21/2010
Groups: Go Science
I can see a few issues with

I can see a few issues with the design of this puzzle. First, it would appear that segments 69 and 70 are locked, so if 70 is part of a helix one can't use the "5" key to get an ideal helix. Second. the band between the two sheet segments (91-92, 99-100) can't be clicked on to create a solidified sheet. Third, the score seems to be hugely negative at all times. Fourth, having the fixed portion in the middle of two loops really constrains what can be done. Just sayin'.

bkoep's picture
User offline. Last seen 56 min 48 sec ago. Offline
Joined: 11/15/2012
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Thank you for the feedback!

This puzzle has been closed and reposted as Puzzle 1650b.

I'm sorry to say we can't address all of these issues. The cutpoints are permanent, and cannot be closed. This is important for keeping the loop frozen in place.

The constraint of having the fixed portion in the middle of the chain is what makes this puzzle especially challenging! Currently, we don't have great automated methods for "growing" a protein design out of a fixed loop like this. We think Foldit players might be better-suited to tackle this kind of problem.

NinjaGreg's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 05/21/2010
Groups: Go Science
What's wrong with this picture?

jamiexq's picture
User offline. Last seen 5 hours 7 min ago. Offline
Joined: 07/31/2011
score won't go above zero

this is broken

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons