1650: B7-2 Binder Design: Stabilize the Loop!
|Name:||1650: B7-2 Binder Design: Stabilize the Loop!|
|Expired:||03/25/2019 - 23:00|
|Description:||Note: This puzzle was closed early due to a miscalibrated score function. The puzzle has been reposted as Puzzle 1650b.
Design a protein to bind B7-2 and block autoimmune reactions! B7-2 is a signal protein in the immune system, and is important for regulating how the immune system distinguishes foreign particles from “self" cells. In some autoimmune disorders, like rheumatoid arthritis, B7-2 can activate the immune system against the body’s own self cells. We want to design a protein that binds B7-2 and blocks it from activating the immune system. Here we’ve provided the target surface of B7-2, along with a a few loop residues from a known binder of B7-2. We want to see if Foldit players can design a folded protein that contains this loop! The B7-2 surface and the binding loop are frozen in place. Good designs should form a well-folded protein that stabilizes the proline-rich binding loop. The starting structure contains 122 residues, but players may add residues at a cost of 55 points each (maximum 130 residues).
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