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1644: Symmetric Dimer Design
Status: Closed

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Comments

bkoep's picture
User offline. Last seen 12 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2400)
Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

spvincent's picture
User offline. Last seen 5 hours 36 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
It would be most helpful to

It would be most helpful to be able to add and delete residues to these symmetry puzzles: is there still some bug that precludes this?

bkoep's picture
User offline. Last seen 12 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: None
Insertions/deletions currently unavailable

I agree! Unfortunately, the underlying Rosetta code for residue insertions/deletions is slightly more complicated for symmetric puzzles, so right now this isn't supported in Foldit.

However, I think there are some ways around the difficulty, so hopefully we can fix this soon!

jeff101's picture
User offline. Last seen 14 hours 11 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Please list the segment count for each monomer.

I would appreciate it if you would list the number of residues (segments) in each monomer on the web pages for puzzles like this. For example, Puzzle 1644 has 70 residues per monomer while Puzzle 1638 had only 65 residues per monomer.

bkoep's picture
User offline. Last seen 12 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: None
Sorry!

Other players have mentioned this as well. We'll try to be better about posting residue counts in future design puzzles!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons