puzzle picture
1640: Unsolved De-novo Freestyle 147: Symmetric Dimer
Status: Closed

Summary

Name: 1640: Unsolved De-novo Freestyle 147: Symmetric Dimer
Status: Closed
Created: 02/21/2019
Points: 100
Expired: 02/28/2019 - 23:00
Difficulty: Intermediate
Description: This is a follow-up to Puzzle 1637, now with C2 symmetry. This protein was originally designed as a symmetric dimer, and we want to see if Foldit players can predict how the symmetric protein was designed to fold and bind. Players may load in solutions from Puzzle 1637. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

Sequence:
PDLAELVVEAAKKLATLLLEATKELVKALGEKEEAKKMMTEAEKTIKEWLKELEDRMRKDPDIKKVIKMATELLATIIEMLTRILLKIQQ
Categories: Overall, Prediction, Symmetry

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Comments

Joined: 06/06/2013
Groups: Gargleblasters
2 dimers at once too much for machine

I didn't do the first de novo, and my machine can barely work a single dimer or trimer at a time. I love symmetry puzzles, so if we could space these puzzles out I would like to work them.

Or PM me what sort of affordable computer I could buy to keep up with Loci :)

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grogar7's picture
User offline. Last seen 16 hours 19 min ago. Offline
Joined: 10/03/2011
previous puzzle results loadable?

Why are the results from the previous monomer puzzle loadable into this puzzle, when this one already has a set aa sequence?

grogar7's picture
User offline. Last seen 16 hours 19 min ago. Offline
Joined: 10/03/2011
errr...I meant previous dimer

errr...I meant previous dimer

frood66's picture
User offline. Last seen 1 hour 9 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
amazing mess

I take my hat off 2 U - I have not seen something so appalling in all the time I have been here.

But it appears that FC have no bounds! lol

frood66's picture
User offline. Last seen 1 hour 9 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
U want us to play this?

looks like FC need to gift about 4000 in dollars or pounds sterling - whichever the greater - to every player.

I may be banned - I cannot see vet or global - but my views remain, Take note FC - please?

grogar7's picture
User offline. Last seen 16 hours 19 min ago. Offline
Joined: 10/03/2011
Apology

I get it now. The original puzzle was a design puzzle. But the loadable results are from denovo 1637 which was a monomer from that original puzzle with a set amino acid sequence. The sequence of this puzzle matches 1637. Sorry for the misunderstanding :\
Not such a mess after all, frood!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons