Contest Info

Name: CHE 8592 Greek Key Challenge 2019
Type: Template
Owner: jakelmer
Start Date: 01/28/19
End Date: 02/12/19
Puzzle: Freestyle Design 40
Description:

In this challenge, your goal is to create a Greek Key motif (see image below) by mutating and manipulating a 40-residue long peptide in FoldIt.

To receive full credit, your protein must satisfy the following requirements:
• There must be 4 beta strands and 3 turns/loops (any length)
• The beta strands must be in the configuration shown above (4-1-2-3)
• One side of the beta sheet should be entirely hydrophobic, while the other is hydrophilic
• There must be a minimum of 9 hydrogen bonds between the beta strand backbones
• The final peptide must be continuous (no cuts)
• However, the protein does not have to be stable when you select “Wiggle All”
• Save and upload your final structure to the Group contest
• Send Dr. Elmer your final amino acid sequence in the following format:
o -strand 1 = xxxxxx (x = amino acid, starting with the first on the left)
o Turn 1 = xxx
o -strand 2 = xxxxxx
o ….and so on for the rest of the turn/loops/strands
o Total number of H-bonds = ? (I will be checking your structures)
Due Date = 2/11/19 (The contest will close after this date)
Here is a video walkthrough if you need additional guidance:
https://vums-web.villanova.edu/Mediasite/Play/c30ba88f95b84c2ea817a58e69f8f33b1d


Registered Contestants

UserScoresort icon
jakelmer0
kwoods87738
robdorrycott7739
MeganLe7741
Jrolle7746
CGerberich7749
michaelmcgarrah7763
JimHughes8513
asmit1458607

Registered Groups

Groupsort iconScore
Villanova ChE8607





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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons