puzzle picture
1629: Symmetric Trimer Design
Status: Closed

Summary

Name: 1629: Symmetric Trimer Design
Status: Closed
Created: 01/25/2019
Points: 100
Expired: 02/01/2019 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C3 symmetry, with three symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). There are no helix restrictions, but all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Contenders22,332100
2Go Science22,16173
3Beta Folders22,10352
4Anthropic Dreams22,07536
5Gargleblasters21,99724

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Comments

bkoep's picture
User offline. Last seen 15 hours 20 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +2100)
Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +3600)
Ensures that at least 72 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Prohibits all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons