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Joined: 01/18/2019
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Hello, I'm Kyle and I'm new to foldit. I am not particularly knowledgeable in the area of protein folding yet, but I am currently studying GGPPS in A. thaliana (At4g36810 is the gene). I am getting a little frustrated that I cannot upload/input an extended chain of the 371 amino acids to try to fold it. Apparently I need to make a 'contest' that is based on existing puzzles? Is this to prevent a whole ton of people from uploading a bunch of sequences and bogging down the site? Is there any way to do this offline? Has someone else already made this 'contest'? Thanks for understanding my beginner's ignorance.-Kyle

Joined: 05/19/2017
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Foldit's capacity may be limited

Hi! Welcome to Foldit!

I don't know the backend specifics (perhaps some of the older veterans or the devs can fill you in there) but what I do know is that 200 residues is already close to pushing the limits of the game's stability. If you've taken a crack at the Aflatoxin Puzzle series (old expired puzzles may be loaded in regardless of expiration time) then you'll see that over time, large chunks of the enzyme being modeled were taken out for performance reasons.

Though, since you said you're studying a particular protein already, I think this might be of interest for you. https://doi.org/10.1093/bioinformatics/btx283
Foldit Standalone may be more pertinent for loading in stuff that you might already have.

If you need other help with the game, feel free to ask in the IRC chat, here, or otherwise! I livestream the game every Friday over on my Twitch channel, which there is a link to on my profile.

LociOiling's picture
User offline. Last seen 3 hours 10 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
Foldit standalone

Here's the link describing the standalone version: https://els.comotion.uw.edu/express_license_technologies/foldit

Joined: 01/18/2019
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Thank you so much for the

Thank you so much for the information - I will definitely look into the standalone!

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