Core Existence: Monomer (max +3000)
Ensures that at least 21 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.
Core Existence: Complex (max +4650)
Ensures that at least 72 residues are buried in the core of the entire complex (including the interface between monomer units).
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).
SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
How many extra pmts can you get on the two core Exustences? I am already above the score that is given.
Can you share your solution with scientists? There may be a bug, and that should help us track it down.
The puzzle configuration is definitely set to max out at +3000/+4650 pts for the Monomer/Complex objectives.
Intentional or oversight? I don't see either in the tools.
This is also odd. Both the Rama Map and Blueprint Tool should be available, and I can use them just fine here. Are other people also seeing this issue?
Monomer max +3050
Complex max +4700
Can you share your solution with scientists? This seems like a bug; those objectives should max out at +3000 and +4650.
These puzzles have a problem.
They don't seems to allow 360 degree rotation.
They are very madding to work on.
Hopefully some of the comments below for symmetry
puzzles 1499 and 1499c will help with this puzzle:
Can you say more about the rotation problem?
Do you mean you're having trouble rotating the camera (by clicking and dragging the background)? Or are you having trouble rotating the protein (using the move tool)?
Does the client crash, or do the tools stop working while Foldit continues to run?
I'm not sure what rotation problem dbuske was describing
above. It might be similar to what I experienced in Puzzles
1499 & 1499c. It might be like what Skippysk8s encountered
last March (https://fold.it/portal/node/2004913), perhaps
also for Puzzles 1499 & 1499c.
My own experience with Puzzle 1619b is that it is very slow.
Even simple things like Restore Recent Best, scrolling thru
Chat, and Freeze/Unfreeze have been much slower than usual.
I got a Recipe to evo a teammate's solution at least. This
Recipe also ran much slower than usual. I'll probably not
try to solo on this puzzle.
I did glance at the Rama Map & Blueprint Tool in the
Original Interface when I started this puzzle. They looked
normal. I was also able to rotate two of my teammates'
solutions around to see which residues were already involved
in hydrogen bond networks. Things behaved fine in my hands,
but I think all the clients I used were old ones, like from