puzzle picture
1610: Symmetric Dimer Design: Hydrogen Bond Networks
Status: Closed

Soloists



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 14 hours 57 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Core Existence: Monomer (max +2500)
Ensures that at least 25 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.

Core Existence: Complex (max +3000)
Ensures that at least 60 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).

SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

grogar7's picture
User offline. Last seen 2 weeks 2 days ago. Offline
Joined: 10/03/2011
Apparent bug in puzzle 1610

Scoring engine is treating my entire symmetric chain as a non-ideal loop! That does not seem right!?

bkoep's picture
User offline. Last seen 14 hours 57 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Strange

You're right, that definitely shouldn't happen. Can you share this solution with scientists, and I'll take a closer look?

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons