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1610: Symmetric Dimer Design: Hydrogen Bond Networks
Status: Closed
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Evolvers
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| 1 | Bletchley Park 9 8 | Contenders | 24,934 | 100 | | 2 | Galaxie 1 2 | Anthropic Dreams | 24,874 | 96 | | 3 | phi16 11 32 | Anthropic Dreams | 24,731 | 92 | | 4 | robgee 7 10 | Anthropic Dreams | 24,703 | 87 | | 5 | alcor29 5 7 | Anthropic Dreams | 24,666 | 83 | | 6 | alwen 46 1295 | Anthropic Dreams | 24,644 | 80 | | 7 | gmn 4 5 | Anthropic Dreams | 24,613 | 76 | | 8 | spvincent 30 13 | Contenders | 24,182 | 72 | | 9 | LociOiling 2 1 | Beta Folders | 24,160 | 69 | | 10 | smilingone 46 1295 | Beta Folders | 24,147 | 65 | | 11 | actiasluna 46 1295 | Gargleblasters | 24,146 | 62 | | 12 | Mark- 46 1295 | Contenders | 24,109 | 59 | | 13 | reefyrob 46 1295 | Beta Folders | 24,058 | 56 | | 14 | Blipperman 34 42 | Gargleblasters | 23,926 | 53 | | 15 | toshiue 26 148 | Go Science | 23,544 | 51 | | 16 | Bruno Kestemont 3 3 | Go Science | 23,502 | 48 | | 17 | jausmh 21 27 | Marvin's bunch | 23,498 | 46 | | 18 | Hollinas 46 1295 | Go Science | 23,462 | 43 | | 19 | Phyx 46 203 | Go Science | 23,436 | 41 | | 20 | silent gene 46 493 | Go Science | 23,328 | 39 | | 21 | fisherlr777 46 1295 | Go Science | 23,307 | 37 | | 22 | ManVsYard 46 1003 | Gargleblasters | 23,214 | 35 | | 23 | Maerlyn138 46 1295 | Go Science | 23,197 | 33 | | 24 | Hellcat6 40 94 | Go Science | 23,194 | 31 | | 25 | Amphimixus 46 1295 | Go Science | 22,580 | 29 | Need this puzzle? Log in to download.
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Core Existence: Monomer (max +2500)
Ensures that at least 25 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.
Core Existence: Complex (max +3000)
Ensures that at least 60 residues are buried in the core of the entire complex (including the interface between monomer units).
HBond Network
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).
SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.