puzzle picture
1608: Symmetric Dimer Design: Hydrogen Bond Networks
Status: Closed

Soloists



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 4 hours 20 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.

Core Existence: Complex (max +2100)
Ensures that at least 42 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).

SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.

toshiue's picture
User offline. Last seen 1 week 3 days ago. Offline
Joined: 01/31/2016
Groups: Go Science
two 1607s

this one is really 1608?

bkoep's picture
User offline. Last seen 4 hours 20 min ago. Offline
Joined: 11/15/2012
Groups: None
Yes!

Sorry for the oversight, this has been corrected!

dbuske's picture
User offline. Last seen 15 hours 2 min ago. Offline
Joined: 09/22/2011
Groups: Beta Folders
2nd chain

I cannot find the 2nd chain, then I lost the 1st chain.
Q does not work to find the 1st chain.

Joined: 01/24/2016
Groups: None
That has happened to me in

That has happened to me in the past. If the 2 chains get too far apart, then Q will not work. Q will center the midpoint of the 2 chains. Also, if you rotate them like that, the "dimming" lighting effect will make the 1st chain disappear.

Either move the chain so that the ends furthest apart are nearer;

from: 111111111111111 2222222222222222

to: 111111111111111
222222222222222

at the start of the game, or use a band to anchor one end of chain 1, before running any recipes.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons