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Joined: 11/15/2012
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Objectives

Core Existence: Monomer (max +2300)
Ensures that at least 23 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2700)
Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

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Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons