puzzle picture
1605: Symmetric Dimer Design
Status: Closed

Summary

Name: 1605: Symmetric Dimer Design
Status: Closed
Created: 11/30/2018
Points: 100
Expired: 12/07/2018 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). There are no helix restrictions, but all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Gargleblasters22,689100
2Contenders22,48565
3Beta Folders22,31641
4Go Science22,30824
5Anthropic Dreams22,17214

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1actiasluna 18 6 Gargleblasters22,689100
2johnmitch 80 7  22,49196
3Mark- 36 19 Contenders22,47992
4isaksson 13 21 Go Science22,30887
5LociOiling 2 2 Beta Folders22,24583


Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 1 hour 12 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +2300)
Ensures that at least 23 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2700)
Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons