puzzle picture
1602: Symmetric Dimer Design
Status: Closed

Summary

Name: 1602: Symmetric Dimer Design
Status: Closed
Created: 11/23/2018
Points: 100
Expired: 11/30/2018 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). However, there other stringent objectives in effect: solutions may have no more than 50% of residues in helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Gargleblasters25,032100
2Contenders24,94870
3Beta Folders24,46847
4Void Crushers24,36030
5Anthropic Dreams24,32919

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User is online Online
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +2500)
Ensures that at least 25 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +3100)
Ensures that at least 62 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Joined: 06/06/2013
Groups: Gargleblasters
ideal loops

just a note that some of my "ideal loops" showed up as non-ideal even with blueprint tool holding them locked.... I think it is me, but it is frustrating

bkoep's picture
User is online Online
Joined: 11/15/2012
Groups: None
Shared?

Can you share those solutions with us? Or let us know which Building Blocks are setting off the Ideal Loops objective?

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons