puzzle picture
1600: Symmetric Dimer Design
Status: Closed

Summary

Name: 1600: Symmetric Dimer Design
Status: Closed
Created: 11/15/2018
Points: 100
Expired: 11/22/2018 - 23:00
Difficulty: Intermediate
Description: This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). However, solutions may have no more than 50% of residues in helices. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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2Gargleblasters20,68073
3Contenders20,30652
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Comments

bkoep's picture
User offline. Last seen 1 hour 22 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2400)
Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons