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1573b: HIV Protease Inhibitor Small Molecule Design: Round 3b
Status: Closed

Summary

Name: 1573b: HIV Protease Inhibitor Small Molecule Design: Round 3b
Status: Closed
Created: 11/03/2018
Points: 100
Expired: 11/12/2018 - 23:00
Difficulty: Expert
Description:

The goal of this puzzle is to change the chemical structure of the ligand in the center of the protein to find better inhibitors of HIV protease. It's less about changing the protein to fit the ligand, and more about changing the ligand to fit the protein. Use the Ligand Design tool in the selection interface (or the "Ligand Design" mode in the original interface) to alter the chemical identity of the inhibitor.

This is a repost of puzzle 1573, now that issues with hanging in that puzzle should be addressed. The big change on round 3 versus rounds 1 and 2 is how we are scoring the small molecules. We looked at all the interesting designs from previous rounds, and altered scoring (primarily via objectives) to encourage more drug-like small molecules.

See the previous blog post for more information on small molecule design, and Puzzles 1432, 1519 and 1573 for the previous rounds. You should be able to load saved structures from round 2 (puzzle 1519) and round 3 (puzzle 1573) into this puzzle.

Categories: Pilot, Small Molecule Design

Top Groups

RankGroupScorePoints
1freefolder21,273100
2Void Crushers21,13671
3Go Science20,79549
4Anthropic Dreams20,46533
5Beta Folders20,20322

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1ernest.chemist 76 111 freefolder21,273100
2Marvelz 76 79  21,24997
3Mike Cassidy 76 50 Void Crushers21,13694
4fiendish_ghoul 76 5  20,70990
5u.w. 76 86  20,66987


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Comments

rmoretti's picture
User offline. Last seen 3 hours 32 min ago. Offline
Joined: 01/15/2010
Groups: None
Objectives

Molecular Weight (max 2000 pts): Penalizes larger (over 630 Da) small molecules.

Number of Rotatable Bonds (max 1000 pts): Penalizes very flexible small molecules. (Click "Show" to highlight rotatable bonds.) Bonds in rings don't count as "rotatable".

Ligand Substructures (max 1000 pts): Penalizes substructures which either occur rarely in drug like molecules, or were over-represented in previous rounds:

Synthetic Accessibility (max 1000 pts): Penalizes compounds which are harder to make. (Click "Show" to show troublesome areas of the molecule.)

Ligand Hydrogen Bond Acceptors (max 1000 pts): Penalizes compounds with too many (14 or more) hydrogen bond acceptors.

Ligand Hydrogen Bond Donors (max 1000 pts): Penalizes compounds with too many (7 or more) hydrogen bond donors.

Ligand cLogP (max 1000 pts): Penalizes compounds which are too hydrophobic.

dbuske's picture
User offline. Last seen 12 hours 1 min ago. Offline
Joined: 09/22/2011
Groups: Beta Folders
Not showing

I am running devprev and this hiv puzzle does not show up.

robgee's picture
User offline. Last seen 1 day 14 hours ago. Offline
Joined: 07/26/2013
IsoSurface view will not turn off

Once IsoSurface view is turned on, I do not seem to be able to switch it off again.

Joined: 02/08/2012
Groups: None
Foldit Unresponsive

I tried adding benzene and Foldit became unresponsive.

Brand new computer too.

Joined: 02/08/2012
Groups: None
correct molecule

cyclohexan.

Also, Color: Ligand Specific; View Protein: Cartoon; View Hydrogens: Show All H; View Sidechains: Show all.

Joined: 09/22/2017
Groups: Beta Folders
Please

penalize hydroxylamine functionality as many submissions appear to have this rather reactive functionality in them

Joined: 06/24/2008
Groups: Void Crushers
Something to look into for future puzzles

I keep randomly crashing; here is the crash report:

Process: game_dynamic [1477]
Path: /Applications/Foldit.app/Contents/MacOS/game_dynamic
Identifier: edu.washington.foldit
Version: 1.0
Code Type: X86 (Native)
Parent Process: ??? [1]
Responsible: game_dynamic [1477]
User ID: 501

Date/Time: 2018-11-11 18:20:35.885 -0500
OS Version: Mac OS X 10.14.1 (18B75)
Report Version: 12
Anonymous UUID: 02F110A1-8FE4-6A66-D372-CDB5BC14E36B

Sleep/Wake UUID: FB43E743-06D5-4332-8D1D-467CCE8F8213

Time Awake Since Boot: 28000 seconds
Time Since Wake: 28000 seconds

System Integrity Protection: enabled

Crashed Thread: 0 Dispatch queue: com.apple.main-thread

Exception Type: EXC_CRASH (SIGABRT)
Exception Codes: 0x0000000000000000, 0x0000000000000000
Exception Note: EXC_CORPSE_NOTIFY

Application Specific Information:
terminating with uncaught exception of type utility::excn::Exception:

File: ../src/numeric/xyzVector.hh:665
Cannot normalize xyzVector of length() zero
abort() called

Thread 0 Crashed:: Dispatch queue: com.apple.main-thread
0 libsystem_kernel.dylib 0xa7b52a9a __pthread_kill + 10
1 libsystem_pthread.dylib 0xa7c01165 pthread_kill + 289
2 libsystem_c.dylib 0xa7ab062b abort + 133
3 libc++abi.dylib 0xa5650f27 abort_message + 134
4 libc++abi.dylib 0xa56510d4 default_terminate_handler() + 237
5 game_library.dylib 0x03a06dcb game::application::terminate_handler() + 263
6 libc++abi.dylib 0xa565be1d std::__terminate(void (*)()) + 14
7 libc++abi.dylib 0xa565bbde __cxxabiv1::failed_throw(__cxxabiv1::__cxa_exception*) + 29
8 libc++abi.dylib 0xa564f7e1 __cxa_throw + 107
9 game_library.dylib 0x013e8148 numeric::xyzVector::normalize() + 280
10 game_library.dylib 0x00d323a5 core::kinematics::Stub::from_four_points(numeric::xyzVector const&, numeric::xyzVector const&, numeric::xyzVector const&, numeric::xyzVector const&) + 55
11 game_library.dylib 0x014151e6 core::scoring::lkball::WaterBuilder::WaterBuilder(numeric::xyzVector const&, core::conformation::Residue const&, unsigned long, unsigned long, unsigned long) + 120
12 game_library.dylib 0x01418584 core::scoring::lkball::setup_water_builders_for_residue_type(core::chemical::ResidueType const&, bool, utility::vector1 >, std::__1::allocator > > >&) + 470
13 game_library.dylib 0x014191ca core::scoring::lkball::LKBallDatabase::initialize_residue_type(core::chemical::ResidueType const&) + 652
14 game_library.dylib 0x0141a6f7 core::scoring::lkball::LKB_ResidueInfo::initialize(core::chemical::ResidueType const&) + 287
15 game_library.dylib 0x0141a525 core::scoring::lkball::LKB_ResidueInfo::LKB_ResidueInfo(core::conformation::Residue const&) + 171
16 game_library.dylib 0x013fa894 core::scoring::lkball::update_cached_lkb_resinfo(core::conformation::Residue const&, basic::datacache::BasicDataCache&, bool) + 72
17 game_library.dylib 0x013fbfbe core::scoring::lkball::LK_BallEnergy::setup_for_scoring_for_residue(core::conformation::Residue const&, core::pose::Pose const&, core::scoring::ScoreFunction const&, basic::datacache::BasicDataCache&) const + 22
18 game_library.dylib 0x00f67aab core::scoring::ScoreFunction::setup_for_scoring(core::pose::Pose&) const + 461
19 game_library.dylib 0x00f676e4 core::scoring::ScoreFunction::operator()(core::pose::Pose&) const + 260
20 game_library.dylib 0x036e3218 interactive::util::ReferencePoseInfo::score_pose(interactive::util::access_ptr, core::scoring::ScoreFunction&, bool) const + 344
21 game_library.dylib 0x037b3a78 standalone::application::StandaloneApplication::score_pose(interactive::util::access_ptr, bool) + 276
22 game_library.dylib 0x037b9d5b standalone::application::StandaloneApplication::pose_edit() + 141
23 game_library.dylib 0x03a1e229 game::application::GameApplication::pose_edit() + 77
24 game_library.dylib 0x03808286 boost::detail::function::void_function_obj_invoker0, boost::_bi::list1 > >, void>::invoke(boost::detail::function::function_buffer&) + 32
25 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35
26 game_library.dylib 0x036e853d interactive::util::WrappedPose::call_edit_callback() + 109
27 game_library.dylib 0x034864fb interactive::application::actions::ligand::update_game_ligand_(interactive::util::access_ptr, boost::shared_ptr, unsigned long, bool) + 344
28 game_library.dylib 0x03486a11 interactive::application::actions::ligand::update_ligand(interactive::util::access_ptr, boost::shared_ptr, unsigned long, bool, bool, bool) + 250
29 game_library.dylib 0x0347e962 interactive::application::actions::ligand::ActionReplaceAtom::on_instant_run() + 698
30 game_library.dylib 0x035702c5 interactive::application::shared::ToolActionInstant::do_launch() + 51
31 game_library.dylib 0x0356f4a4 interactive::application::shared::ToolAction::launch() + 188
32 game_library.dylib 0x0348492b interactive::application::actions::ligand::ActionReplaceAtomFloatMenu::on_clickity_clackity(core::chemical::element::Elements const&) + 273
33 game_library.dylib 0x034856da boost::detail::function::void_function_obj_invoker0, boost::_bi::list2, boost::_bi::value > >, void>::invoke(boost::detail::function::function_buffer&) + 38
34 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35
35 game_library.dylib 0x03622449 interactive::gui::Button::on_click() + 47
36 game_library.dylib 0x03620fa7 interactive::gui::Button::generate_click() + 55
37 game_library.dylib 0x036224fb interactive::gui::Button::on_mouse_up(interactive::gui::Point2D const&, int) + 63
38 game_library.dylib 0x0365a2e8 interactive::gui::TopLevel::on_mouse_up(interactive::gui::Point2D const&, int) + 162
39 game_library.dylib 0x0366cd4c interactive::guiwrapper::GUIWrapper::generic_mouse_button_func(int, bool, int, int) + 260
40 game_library.dylib 0x03674330 void boost::_bi::list5, boost::_bi::value, boost::_bi::value, boost::_bi::value, boost::_bi::value >::operator(), boost::_bi::list0>(boost::_bi::type, boost::_mfi::mf4&, boost::_bi::list0&, int) + 64
41 game_library.dylib 0x036742eb boost::detail::function::void_function_obj_invoker0, boost::_bi::list5, boost::_bi::value, boost::_bi::value, boost::_bi::value, boost::_bi::value > >, void>::invoke(boost::detail::function::function_buffer&) + 27
42 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35
43 game_library.dylib 0x0366caf5 interactive::guiwrapper::GUIWrapper::enqueue_event(boost::function) + 41
44 game_library.dylib 0x03672429 cocoa_wrapper_mouse_button + 296
45 game_library.dylib 0x03671bd0 -[CocoaOpenGLView anyMouseUp:withButton:] + 121
46 game_library.dylib 0x03671895 -[CocoaOpenGLView mouseUp:] + 31
47 com.apple.AppKit 0x91639a9a -[NSWindow(NSEventRouting) _reallySendEvent:isDelayedEvent:] + 593
48 com.apple.AppKit 0x9163960b -[NSWindow(NSEventRouting) sendEvent:] + 427
49 com.apple.AppKit 0x914e500d -[NSApplication(NSEvent) sendEvent:] + 3521
50 com.apple.AppKit 0x914d2a4e -[NSApplication run] + 826
51 game_library.dylib 0x03674f7a cocoa_glue_start + 981
52 game_library.dylib 0x03673581 interactive::guiwrapper::cocoa::CocoaWrapper::start() + 39
53 game_library.dylib 0x03406871 interactive::application::interactive_main(utility::vector1, std::__1::allocator >, std::__1::allocator, std::__1::allocator > > > const&, boost::function, boost::function, bool) + 4412
54 game_library.dylib 0x03aa2148 game::application::game_main(int, char**, char const*, game::application::ExecutableKindEnum) + 2328
55 game_library.dylib 0x0022e7d0 library_main + 32
56 edu.washington.foldit 0x000ac25a run_library_main(std::__1::basic_string, std::__1::allocator > const&, bool, std::__1::basic_string, std::__1::allocator > const&, int&, int, char**, std::__1::basic_string, std::__1::allocator >&) + 170
57 edu.washington.foldit 0x000abef2 main + 319
58 edu.washington.foldit 0x000a9605 start + 53

Thread 1:
0 libsystem_pthread.dylib 0xa7bfd7c0 start_wqthread + 0
1 ??? 0x54485244 0 + 1414025796

Thread 2:
0 libsystem_pthread.dylib 0xa7bfd7c0 start_wqthread + 0
1 ??? 0x54485244 0 + 1414025796

Thread 3:: com.apple.audio.IOThread.client
0 libsystem_kernel.dylib 0xa7b4ce22 mach_msg_trap + 10
1 libsystem_kernel.dylib 0xa7b4d35f mach_msg + 47
2 com.apple.audio.CoreAudio 0x934e7a82 HALB_MachPort::SendMessageWithReply(unsigned int, unsigned int, unsigned long, unsigned long, mach_msg_header_t*, bool, unsigned int) + 126
3 com.apple.audio.CoreAudio 0x934bfc3b HALB_MachPort::SendSimpleMessageWithSimpleReply(unsigned int, unsigned int, int, int&, bool, unsigned int) + 49
4 com.apple.audio.CoreAudio 0x934bcbcb HALC_ProxyIOContext::IOWorkLoop() + 1589
5 com.apple.audio.CoreAudio 0x934bc342 HALC_ProxyIOContext::IOThreadEntry(void*) + 236
6 com.apple.audio.CoreAudio 0x934f06d0 invocation function for block in HALC_ProxyIOContext::HALC_ProxyIOContext(unsigned long, unsigned int) + 20
7 com.apple.audio.CoreAudio 0x934bbfcf HALB_IOThread::Entry(void*) + 71
8 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
9 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
10 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 4:: com.apple.NSEventThread
0 libsystem_kernel.dylib 0xa7b4ce22 mach_msg_trap + 10
1 libsystem_kernel.dylib 0xa7b4d35f mach_msg + 47
2 com.apple.CoreFoundation 0x938e8ad9 __CFRunLoopServiceMachPort + 289
3 com.apple.CoreFoundation 0x938e819a __CFRunLoopRun + 3196
4 com.apple.CoreFoundation 0x938e7221 CFRunLoopRunSpecific + 584
5 com.apple.CoreFoundation 0x9390021f CFRunLoopRunInMode + 82
6 com.apple.AppKit 0x914e1bf3 _NSEventThread + 165
7 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
8 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
9 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 5:
0 libsystem_kernel.dylib 0xa7b50792 __semwait_signal + 10
1 libsystem_c.dylib 0xa7acdd97 nanosleep$UNIX2003 + 189
2 libsystem_c.dylib 0xa7acdc84 usleep$UNIX2003 + 54
3 game_library.dylib 0x036e75c7 interactive::util::Thread::sleep(double) + 47
4 game_library.dylib 0x0352a3c1 interactive::application::appposeview::VoidGeom::VoidThread::operator()() + 123
5 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
6 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
7 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
8 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
9 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 6:
0 libsystem_kernel.dylib 0xa7b4f992 __psynch_mutexwait + 10
1 libsystem_pthread.dylib 0xa7bff091 _pthread_mutex_firstfit_lock_wait + 95
2 libsystem_pthread.dylib 0xa7bfc7dd _pthread_mutex_firstfit_lock_slow + 343
3 libsystem_pthread.dylib 0xa7bfc450 pthread_mutex_lock + 146
4 game_library.dylib 0x038e8106 boost::unique_lock::lock() + 38
5 game_library.dylib 0x0351f09f interactive::application::appposeview::HydrophobicComposite::HydroThread::operator()() + 49
6 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
7 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
8 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
9 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
10 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 7:
0 libsystem_kernel.dylib 0xa7b50792 __semwait_signal + 10
1 libsystem_c.dylib 0xa7acdd97 nanosleep$UNIX2003 + 189
2 libsystem_c.dylib 0xa7acdc84 usleep$UNIX2003 + 54
3 game_library.dylib 0x036e75c7 interactive::util::Thread::sleep(double) + 47
4 game_library.dylib 0x03526eb8 interactive::application::appposeview::ResidueBurialComposite::ResidueBurialThread::operator()() + 176
5 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
6 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
7 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
8 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
9 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 8:
0 libsystem_kernel.dylib 0xa7b50792 __semwait_signal + 10
1 libsystem_c.dylib 0xa7acdd97 nanosleep$UNIX2003 + 189
2 libsystem_c.dylib 0xa7acdc84 usleep$UNIX2003 + 54
3 game_library.dylib 0x036e75c7 interactive::util::Thread::sleep(double) + 47
4 game_library.dylib 0x037c9bb5 standalone::application::StandaloneApplication::autosave_thread_body() + 53
5 game_library.dylib 0x03808286 boost::detail::function::void_function_obj_invoker0, boost::_bi::list1 > >, void>::invoke(boost::detail::function::function_buffer&) + 32
6 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35
7 game_library.dylib 0x036e75f9 interactive::util::Thread::operator()() + 45
8 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
9 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
10 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
11 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
12 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 9:
0 libsystem_kernel.dylib 0xa7b4f992 __psynch_mutexwait + 10
1 libsystem_pthread.dylib 0xa7bff091 _pthread_mutex_firstfit_lock_wait + 95
2 libsystem_pthread.dylib 0xa7bfc7dd _pthread_mutex_firstfit_lock_slow + 343
3 libsystem_pthread.dylib 0xa7bfc450 pthread_mutex_lock + 146
4 game_library.dylib 0x038e8106 boost::unique_lock::lock() + 38
5 game_library.dylib 0x039e04aa game::application::BoincThread::send_boinc(game::application::PollOverride) + 122
6 game_library.dylib 0x039e0002 game::application::BoincThread::periodically_send_and_check_boinc() + 78
7 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
8 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
9 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
10 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
11 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 10:
0 libsystem_kernel.dylib 0xa7b53cea __select + 10
1 game_library.dylib 0x03b0e6be game::util::IRC::run(boost::function) + 1426
2 game_library.dylib 0x03a3c31a game::application::IRCThread::operator()() + 1006
3 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
4 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
5 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
6 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
7 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 11:
0 libsystem_pthread.dylib 0xa7bfd7c0 start_wqthread + 0
1 ??? 0x54485244 0 + 1414025796

Thread 12:
0 game_library.dylib 0x00538ed8 DistGeom::DistViolationContrib::getGrad(double*, double*) const + 298
1 game_library.dylib 0x004f129b ForceFields::ForceField::calcGrad(double*, double*) + 85
2 game_library.dylib 0x004f1a10 ForceFieldsHelper::calcGradient::operator()(double*, double*) const + 66
3 game_library.dylib 0x004f013c int BFGSOpt::minimize(unsigned int, double*, double, unsigned int&, double&, ForceFieldsHelper::calcEnergy, ForceFieldsHelper::calcGradient, double, unsigned int) + 823
4 game_library.dylib 0x004ef834 ForceFields::ForceField::minimize(unsigned int, double, double) + 184
5 game_library.dylib 0x005206a3 RDKit::DGeomHelpers::_embedPoints(std::__1::vector >*, boost::shared_ptr, bool, double, bool, unsigned int, double, double, int, unsigned int, std::__1::vector, std::__1::allocator > > const*, bool, bool, bool, std::__1::vector, std::__1::allocator > > const&, std::__1::vector >, std::__1::allocator > > > const&, std::__1::vector >, std::__1::allocator > > > const&, std::__1::vector >, std::__1::vector > >, std::__1::allocator >, std::__1::vector > > > > const&, std::__1::vector >, std::__1::allocator > > > const&, std::__1::vector > const&) + 613
6 game_library.dylib 0x0052302d RDKit::DGeomHelpers::detail::embedHelper_(int, int, RDKit::DGeomHelpers::detail::EmbedArgs*) + 577
7 game_library.dylib 0x005221f8 RDKit::DGeomHelpers::EmbedMultipleConfs(RDKit::ROMol&, std::__1::vector >&, unsigned int, int, unsigned int, int, bool, bool, double, bool, unsigned int, double, std::__1::map, std::__1::allocator > > const*, double, bool, bool, bool, bool, bool, double) + 2434
8 game_library.dylib 0x01ed0d0b protocols::fragment_rotamers::RDKitRotamers::generate_conformers(core::chemical::ResidueType const&, unsigned long, bool, std::__1::atomic*) + 315
9 game_library.dylib 0x03730b00 interactive::util::ligand::ThreadedRDKitRotamerLibrarySpecification::generate_library(core::chemical::ResidueType const&) + 76
10 game_library.dylib 0x037312ce boost::detail::function::void_function_obj_invoker0, boost::_bi::list2, boost::_bi::value > >, void>::invoke(boost::detail::function::function_buffer&) + 38
11 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35
12 game_library.dylib 0x036e75f9 interactive::util::Thread::operator()() + 45
13 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
14 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
15 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
16 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
17 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 0 crashed with X86 Thread State (32-bit):
eax: 0x00000000 ebx: 0x001eea40 ecx: 0xbff56dcc edx: 0x00000000
edi: 0xa7c01052 esi: 0x0000002d ebp: 0xbff56de8 esp: 0xbff56dcc
ss: 0x00000023 efl: 0x00000206 eip: 0xa7b52a9a cs: 0x0000000b
ds: 0x00000023 es: 0x00000023 fs: 0x00000000 gs: 0x0000000f
cr2: 0xa9ecf360

Logical CPU: 0
Error Code: 0x00080148
Trap Number: 132

Binary Images:
0xa8000 - 0xadffb +edu.washington.foldit (1.0) /Applications/Foldit.app/Contents/MacOS/game_dynamic
0x1a8000 - 0x1ecacf dyld (635.2) /usr/lib/dyld
0x22d000 - 0x4dfdff7 +game_library.dylib (1) /Applications/Foldit.app/Contents/Resources/cmp-binary-013106a6d1e90f252e6eff463f193a5e/game_library.dylib
0xb5ce000 - 0xb5d1047 libobjc-trampolines.dylib (750.1) <57098857-AC21-369F-94CD-3CFC8AFE060A> /usr/lib/libobjc-trampolines.dylib
0xb603000 - 0xb607ff7 com.apple.audio.AppleHDAHALPlugIn (282.10 - 282.10) /System/Library/Extensions/AppleHDA.kext/Contents/PlugIns/AppleHDAHALPlugIn.bundle/Contents/MacOS/AppleHDAHALPlugIn
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0x9e3f7000 - 0x9e400fff com.apple.coreservices.BackgroundTaskManagement (1.0 - 57.1) /System/Library/PrivateFrameworks/BackgroundTaskManagement.framework/Versions/A/BackgroundTaskManagement
0x9e401000 - 0x9e4a6ff3 com.apple.backup.framework (1.10 - ???) <3894CB14-6619-33F1-BF5A-40A2D72014EA> /System/Library/PrivateFrameworks/Backup.framework/Versions/A/Backup
0x9e5eb000 - 0x9e5f4ff7 com.apple.CommonAuth (4.0 - 2.0) /System/Library/PrivateFrameworks/CommonAuth.framework/Versions/A/CommonAuth
0x9ea72000 - 0x9ea85fff com.apple.CoreEmoji (1.0 - 69.19.8) /System/Library/PrivateFrameworks/CoreEmoji.framework/Versions/A/CoreEmoji
0x9eaf3000 - 0x9eb66ff7 com.apple.CoreNLP (1.0 - 130.15.22) /System/Library/PrivateFrameworks/CoreNLP.framework/Versions/A/CoreNLP
0x9ec12000 - 0x9ec44ffb com.apple.CoreServicesInternal (357 - 357) <007C2DA7-D0D5-3518-9EEB-1C6AD3329A5A> /System/Library/PrivateFrameworks/CoreServicesInternal.framework/Versions/A/CoreServicesInternal
0x9ec45000 - 0x9ecd7ff3 com.apple.CoreSymbolication (10.1 - 64460.6) <061956E0-FCC8-3E30-A223-1D9E04BC7BAC> /System/Library/PrivateFrameworks/CoreSymbolication.framework/Versions/A/CoreSymbolication
0x9ecd8000 - 0x9edfcffb com.apple.coreui (2.1 - 498.46) /System/Library/PrivateFrameworks/CoreUI.framework/Versions/A/CoreUI
0x9edfd000 - 0x9eed1fff com.apple.CoreUtils (5.7.4 - 574.17) /System/Library/PrivateFrameworks/CoreUtils.framework/Versions/A/CoreUtils
0x9ef24000 - 0x9ef81ffb com.apple.framework.CoreWiFi (13.0 - 1370.8) /System/Library/PrivateFrameworks/CoreWiFi.framework/Versions/A/CoreWiFi
0x9ef82000 - 0x9ef93fff com.apple.CrashReporterSupport (10.13 - 938.23) /System/Library/PrivateFrameworks/CrashReporterSupport.framework/Versions/A/CrashReporterSupport
0x9f001000 - 0x9f00effb com.apple.framework.DFRFoundation (1.0 - 211) /System/Library/PrivateFrameworks/DFRFoundation.framework/Versions/A/DFRFoundation
0x9f052000 - 0x9f0c2ffb com.apple.datadetectorscore (7.0 - 590.24) <7BFD3A55-B3F5-3D72-8283-6C96E3B3A0A4> /System/Library/PrivateFrameworks/DataDetectorsCore.framework/Versions/A/DataDetectorsCore
0x9f0c3000 - 0x9f104ff3 com.apple.DebugSymbols (185 - 185) /System/Library/PrivateFrameworks/DebugSymbols.framework/Versions/A/DebugSymbols
0x9f105000 - 0x9f266ff7 com.apple.desktopservices (1.13.1 - ???) /System/Library/PrivateFrameworks/DesktopServicesPriv.framework/Versions/A/DesktopServicesPriv
0x9f577000 - 0x9f9a1ff7 com.apple.vision.FaceCore (3.3.4 - 3.3.4) /System/Library/PrivateFrameworks/FaceCore.framework/Versions/A/FaceCore
0xa2846000 - 0xa2851ffb libGPUSupportMercury.dylib (17.0.37) <3F3D2781-855A-3470-BAD7-F709FA3D9F67> /System/Library/PrivateFrameworks/GPUSupport.framework/Versions/A/Libraries/libGPUSupportMercury.dylib
0xa3547000 - 0xa35bbfff com.apple.Heimdal (4.0 - 2.0) /System/Library/PrivateFrameworks/Heimdal.framework/Versions/A/Heimdal
0xa3893000 - 0xa389affb com.apple.IOAccelerator (400.27 - 400.27) <51398910-F476-39FD-84B8-FF362EA79E6B> /System/Library/PrivateFrameworks/IOAccelerator.framework/Versions/A/IOAccelerator
0xa389b000 - 0xa38b5fff com.apple.IOPresentment (1.0 - 42.6) /System/Library/PrivateFrameworks/IOPresentment.framework/Versions/A/IOPresentment
0xa3911000 - 0xa393affb com.apple.IconServices (379 - 379) <7ED72945-CE7E-370A-844C-22F318A47F6C> /System/Library/PrivateFrameworks/IconServices.framework/Versions/A/IconServices
0xa396f000 - 0xa3a64ff3 com.apple.LanguageModeling (1.0 - 159.15.15) <4A54301F-E641-3718-823C-BA3F27829A93> /System/Library/PrivateFrameworks/LanguageModeling.framework/Versions/A/LanguageModeling
0xa3a65000 - 0xa3aa5fff com.apple.Lexicon-framework (1.0 - 33.15.10) <5A8FF68F-2910-3339-AE91-FD9502690B9A> /System/Library/PrivateFrameworks/Lexicon.framework/Versions/A/Lexicon
0xa3aa9000 - 0xa3aafffb com.apple.LinguisticData (1.0 - 238.15.29) <5A572187-C786-3625-9598-539C4E883339> /System/Library/PrivateFrameworks/LinguisticData.framework/Versions/A/LinguisticData
0xa3c62000 - 0xa3c88ff3 com.apple.spotlight.metadata.utilities (1.0 - 1191.52) <88819CD0-1FBD-3DE6-9DEC-8076E17807C8> /System/Library/PrivateFrameworks/MetadataUtilities.framework/Versions/A/MetadataUtilities
0xa3e90000 - 0xa3ebbff7 com.apple.MultitouchSupport.framework (2410.5 - 2410.5) <1283B2FF-0403-3CA8-8DB1-41338B25BB37> /System/Library/PrivateFrameworks/MultitouchSupport.framework/Versions/A/MultitouchSupport
0xa3fbc000 - 0xa3fc7fff com.apple.NetAuth (6.2 - 6.2) /System/Library/PrivateFrameworks/NetAuth.framework/Versions/A/NetAuth
0xa4023000 - 0xa4078ff3 com.apple.OTSVG (1.0 - ???) <10BE1531-65A0-362C-BE4C-A6DD748FF439> /System/Library/PrivateFrameworks/OTSVG.framework/Versions/A/OTSVG
0xa40c6000 - 0xa40d3ff7 com.apple.PerformanceAnalysis (1.217 - 217) /System/Library/PrivateFrameworks/PerformanceAnalysis.framework/Versions/A/PerformanceAnalysis
0xa416c000 - 0xa4188ff7 com.apple.ProtocolBuffer (1 - 263) <2F48288B-BF75-3978-8D58-6F2CCAEBD3F9> /System/Library/PrivateFrameworks/ProtocolBuffer.framework/Versions/A/ProtocolBuffer
0xa4274000 - 0xa4296fff com.apple.RemoteViewServices (2.0 - 128) <467D0451-4F47-31BC-802C-506D12825857> /System/Library/PrivateFrameworks/RemoteViewServices.framework/Versions/A/RemoteViewServices
0xa4341000 - 0xa435dff7 com.apple.Sharing (1214.9 - 1214.9) /System/Library/PrivateFrameworks/Sharing.framework/Versions/A/Sharing
0xa437d000 - 0xa4407ff3 com.apple.SkyLight (1.600.0 - 336.81.5) <4173E475-159D-33CE-BA7C-6A3E2FA2C369> /System/Library/PrivateFrameworks/SkyLight.framework/Versions/A/SkyLight
0xa4437000 - 0xa4444fff com.apple.SpeechRecognitionCore (5.0.21 - 5.0.21) <35E1860A-D570-352B-90BC-EE8C1DCD3896> /System/Library/PrivateFrameworks/SpeechRecognitionCore.framework/Versions/A/SpeechRecognitionCore
0xa4746000 - 0xa47d1ff3 com.apple.Symbolication (10.1 - 64460.8) <5E9AAA68-1FDB-39D5-91E5-EFA06E3B30C5> /System/Library/PrivateFrameworks/Symbolication.framework/Versions/A/Symbolication
0xa4825000 - 0xa4832fff com.apple.TCC (1.0 - 1) <688BC0E1-0317-3098-B4C9-0B4ACF98CD1E> /System/Library/PrivateFrameworks/TCC.framework/Versions/A/TCC
0xa4833000 - 0xa484affb com.apple.TextureIO (3.8.4 - 3.8.1) <47E8A9FD-00C6-3BEC-9529-C38DE18E764B> /System/Library/PrivateFrameworks/TextureIO.framework/Versions/A/TextureIO
0xa487a000 - 0xa487bff7 com.apple.TrustEvaluationAgent (2.0 - 31.200.1) <5A66CA46-B1DF-3AE7-9322-DCEFBCC5ECC8> /System/Library/PrivateFrameworks/TrustEvaluationAgent.framework/Versions/A/TrustEvaluationAgent
0xa487c000 - 0xa4a04ff3 com.apple.UIFoundation (1.0 - 551) /System/Library/PrivateFrameworks/UIFoundation.framework/Versions/A/UIFoundation
0xa4cb1000 - 0xa4d8ffff com.apple.ViewBridge (401.1 - 401.1) <83B99E89-AA4F-3908-88D1-C01A5FC75D0C> /System/Library/PrivateFrameworks/ViewBridge.framework/Versions/A/ViewBridge
0xa4f06000 - 0xa4f08fff com.apple.loginsupport (1.0 - 1) /System/Library/PrivateFrameworks/login.framework/Versions/A/Frameworks/loginsupport.framework/Versions/A/loginsupport
0xa4f09000 - 0xa4f1afff com.apple.login (3.0 - 3.0) /System/Library/PrivateFrameworks/login.framework/Versions/A/login
0xa5002000 - 0xa5038ff3 libCRFSuite.dylib (41.15.4) <9F58B957-D463-3F34-920C-EDAD6B974CA6> /usr/lib/libCRFSuite.dylib
0xa5039000 - 0xa5043fff libChineseTokenizer.dylib (28.15.3) /usr/lib/libChineseTokenizer.dylib
0xa50dd000 - 0xa50defff libDiagnosticMessagesClient.dylib (107) /usr/lib/libDiagnosticMessagesClient.dylib
0xa5110000 - 0xa52effff libFosl_dynamic.dylib (18.3.2) <8BD9F045-35DE-3DF4-BDBD-4249477B7518> /usr/lib/libFosl_dynamic.dylib
0xa52f7000 - 0xa52f7fff libOpenScriptingUtil.dylib (179) <20609A86-C272-3C1D-8113-F2EDBD7E9FFF> /usr/lib/libOpenScriptingUtil.dylib
0xa5433000 - 0xa5434ffb libSystem.B.dylib (1252.200.5) <9B4EC833-9228-3918-B04B-0778EAFA40AB> /usr/lib/libSystem.B.dylib
0xa5435000 - 0xa5436ffb libThaiTokenizer.dylib (2.15.1) <1D99E78B-27CE-3364-9867-142CA5BFF0D8> /usr/lib/libThaiTokenizer.dylib
0xa5443000 - 0xa5459ff3 libapple_nghttp2.dylib (1.24.1) <54130CCB-854D-3991-B4B7-6E8D256D730A> /usr/lib/libapple_nghttp2.dylib
0xa545a000 - 0xa5485ffb libarchive.2.dylib (54.200.3) <403A8315-E18C-3FEA-A35E-E9E81BCA9780> /usr/lib/libarchive.2.dylib
0xa5486000 - 0xa55d0fef libate.dylib (1.13.8) /usr/lib/libate.dylib
0xa55d4000 - 0xa55d4ff3 libauto.dylib (187) /usr/lib/libauto.dylib
0xa55d5000 - 0xa55e5fff libbsm.0.dylib (39.200.18) <945EC822-9C15-393B-9570-C2143661A840> /usr/lib/libbsm.0.dylib
0xa55e6000 - 0xa55f3ff3 libbz2.1.0.dylib (38.200.3) <307735EB-63BD-3DDA-8BEE-F7D4618E1C03> /usr/lib/libbz2.1.0.dylib
0xa55f4000 - 0xa564dff7 libc++.1.dylib (400.9.4) <7D02B34A-D9AE-36D1-A4DB-D33312BBEFAB> /usr/lib/libc++.1.dylib
0xa564e000 - 0xa5661ffb libc++abi.dylib (400.17) /usr/lib/libc++abi.dylib
0xa5662000 - 0xa5662fff libcharset.1.dylib (51.200.6) <4DD7F3EA-1DA8-344C-B35F-51ED4B548423> /usr/lib/libcharset.1.dylib
0xa5663000 - 0xa5674ff3 libcmph.dylib (6.15.1) <85F62EF8-F0A3-3A40-BA01-152BFD36244A> /usr/lib/libcmph.dylib
0xa5675000 - 0xa568afeb libcompression.dylib (52.200.13) /usr/lib/libcompression.dylib
0xa568b000 - 0xa56a0fff libcoretls.dylib (155.220.1) <95F98DB2-DF19-3E71-9520-7F387C9D985E> /usr/lib/libcoretls.dylib
0xa56a1000 - 0xa56a2fff libcoretls_cfhelpers.dylib (155.220.1) /usr/lib/libcoretls_cfhelpers.dylib
0xa582a000 - 0xa59d4ff3 libcrypto.35.dylib (22.200.4) <1D130129-8B18-38C2-9F3C-83978717D180> /usr/lib/libcrypto.35.dylib
0xa5d4c000 - 0xa5da5ff3 libcups.2.dylib (462.9) <838CDADA-C720-332D-9862-0CE9476B4118> /usr/lib/libcups.2.dylib
0xa5ebb000 - 0xa5ebbfff libenergytrace.dylib (17.200.1) <9BE16C5B-E49F-3416-93E5-D5C88F37D747> /usr/lib/libenergytrace.dylib
0xa5ee9000 - 0xa5eedff3 libgermantok.dylib (17.15.2) <2350BE97-A650-341A-99CC-330EFA85003A> /usr/lib/libgermantok.dylib
0xa5eee000 - 0xa5ef2fff libheimdal-asn1.dylib (520.220.2) <509C256D-758D-3F25-99B3-3A10A22C8565> /usr/lib/libheimdal-asn1.dylib
0xa5f1e000 - 0xa600dff7 libiconv.2.dylib (51.200.6) <52245AF2-9F48-3926-93E9-F70D39E8D6C7> /usr/lib/libiconv.2.dylib
0xa600e000 - 0xa626bff3 libicucore.A.dylib (62108.0.1) <852AA6BF-131A-312B-9083-61E3F45D590C> /usr/lib/libicucore.A.dylib
0xa62b2000 - 0xa62b3fff liblangid.dylib (128.15.1) <1FCAB52F-AFD4-39B4-8AF3-3491EFD89993> /usr/lib/liblangid.dylib
0xa62b4000 - 0xa62ccfff liblzma.5.dylib (10.200.3) <7A9AB6A6-495F-3595-BAB5-2455AE11969A> /usr/lib/liblzma.5.dylib
0xa62e3000 - 0xa6397ff3 libmecab.1.0.0.dylib (779.19.2) /usr/lib/libmecab.1.0.0.dylib
0xa6398000 - 0xa65cdff7 libmecabra.dylib (779.19.2) <02E08BBA-F619-346E-9310-5EBCFF205AD5> /usr/lib/libmecabra.dylib
0xa6795000 - 0xa6addff7 libnetwork.dylib (1229.221.1) <2FFEADA2-525B-39C9-A21F-CF59102AFC22> /usr/lib/libnetwork.dylib
0xa6ade000 - 0xa7253ffb libobjc.A.dylib (750.1) <09652190-E142-3C03-B00F-641CC6C5D704> /usr/lib/libobjc.A.dylib
0xa7257000 - 0xa725bfff libpam.2.dylib (22.200.1) <4B96D846-A31C-3714-9150-494F84C2E682> /usr/lib/libpam.2.dylib
0xa725e000 - 0xa7293ff3 libpcap.A.dylib (79.200.4) <86677AC6-239B-3076-A078-3663D067AF67> /usr/lib/libpcap.A.dylib
0xa72d1000 - 0xa72e9ff7 libresolv.9.dylib (65.200.2) <92AD828A-C7A1-32C8-9774-106D7A518E5E> /usr/lib/libresolv.9.dylib
0xa7338000 - 0xa7501fff libsqlite3.dylib (274.20) <18AFAC11-D0E1-3746-906F-3A3FFF988C6E> /usr/lib/libsqlite3.dylib
0xa7764000 - 0xa7767ffb libutil.dylib (51.200.4) <68F84D39-FAB3-32B5-9424-5D6BC485BFF7> /usr/lib/libutil.dylib
0xa7768000 - 0xa7775ffb libxar.1.dylib (404) <6198D1EE-5DCB-3725-BAA0-8A9630968C6F> /usr/lib/libxar.1.dylib
0xa7776000 - 0xa7855ffb libxml2.2.dylib (32.8) /usr/lib/libxml2.2.dylib
0xa7856000 - 0xa787eff3 libxslt.1.dylib (16.1) <35263404-4E56-3D28-9420-D244F0DCB29F> /usr/lib/libxslt.1.dylib
0xa787f000 - 0xa788efff libz.1.dylib (70.200.4) <3A38FE91-88BA-3C0B-A2C0-FEC852AAE542> /usr/lib/libz.1.dylib
0xa78c8000 - 0xa78ccfff libcache.dylib (81) <0E1883DB-51FE-3426-BD54-C201B9B67251> /usr/lib/system/libcache.dylib
0xa78cd000 - 0xa78d7fff libcommonCrypto.dylib (60118.220.1) <8A60F9D2-57C4-30CE-8DD9-901A3B74E0F9> /usr/lib/system/libcommonCrypto.dylib
0xa78d8000 - 0xa78dffff libcompiler_rt.dylib (63.4) <44CD2149-88F4-3A60-85BE-C9BA3C4CB33C> /usr/lib/system/libcompiler_rt.dylib
0xa78e0000 - 0xa78eafff libcopyfile.dylib (146.200.3) <5BE00D0E-BF42-35B3-B8CB-C84ABFDD7E57> /usr/lib/system/libcopyfile.dylib
0xa78eb000 - 0xa7952ffb libcorecrypto.dylib (602.220.6) <7A457D0C-18BD-33CA-A7BD-BC7067BF12BA> /usr/lib/system/libcorecrypto.dylib
0xa79bc000 - 0xa79f3ff3 libdispatch.dylib (1008.220.2) <77F2627A-0C5E-39CE-BB45-A78F3F4D001A> /usr/lib/system/libdispatch.dylib
0xa79f4000 - 0xa7a23fff libdyld.dylib (635.2) /usr/lib/system/libdyld.dylib
0xa7a24000 - 0xa7a24ffb libkeymgr.dylib (30) /usr/lib/system/libkeymgr.dylib
0xa7a25000 - 0xa7a31ff3 libkxld.dylib (4903.221.2) <12A4DC73-3F0A-3053-BEF9-BFC35C8EC87A> /usr/lib/system/libkxld.dylib
0xa7a32000 - 0xa7a32fff liblaunch.dylib (1336.220.5) <5A89FAD6-006B-31FF-BE5C-BCF6D0877854> /usr/lib/system/liblaunch.dylib
0xa7a33000 - 0xa7a38ff3 libmacho.dylib (921) <16AEFD80-AFAC-348B-BE74-1DD5F1EC22DF> /usr/lib/system/libmacho.dylib
0xa7a39000 - 0xa7a3bffb libquarantine.dylib (86.220.1) <7CFE1933-38C2-3839-B76D-6A54CB452D4D> /usr/lib/system/libquarantine.dylib
0xa7a3c000 - 0xa7a3dffb libremovefile.dylib (45.200.2) <0883CD67-69ED-3A84-ACBC-6354EE5A61F3> /usr/lib/system/libremovefile.dylib
0xa7a3e000 - 0xa7a55fff libsystem_asl.dylib (356.200.4) <5548F4FF-DFB9-34C8-9430-069816762645> /usr/lib/system/libsystem_asl.dylib
0xa7a56000 - 0xa7a56fff libsystem_blocks.dylib (73) /usr/lib/system/libsystem_blocks.dylib
0xa7a57000 - 0xa7ae3ff3 libsystem_c.dylib (1272.200.26) /usr/lib/system/libsystem_c.dylib
0xa7ae4000 - 0xa7ae7fff libsystem_configuration.dylib (963.200.27) <38F3942B-E770-3C7B-B457-829670B7D074> /usr/lib/system/libsystem_configuration.dylib
0xa7ae8000 - 0xa7aebfff libsystem_coreservices.dylib (66) /usr/lib/system/libsystem_coreservices.dylib
0xa7aec000 - 0xa7af1fff libsystem_darwin.dylib (1272.200.26) <85288DAB-860D-3DA8-898B-D8DF56142E3D> /usr/lib/system/libsystem_darwin.dylib
0xa7af2000 - 0xa7af8ffb libsystem_dnssd.dylib (878.200.35) /usr/lib/system/libsystem_dnssd.dylib
0xa7af9000 - 0xa7b4bff7 libsystem_info.dylib (517.200.9) <4AA8F291-4901-33A3-A148-1FBFFF01597A> /usr/lib/system/libsystem_info.dylib
0xa7b4c000 - 0xa7b73ff7 libsystem_kernel.dylib (4903.221.2) <18DEEB60-1DBD-3CD2-BCB2-481CAE013562> /usr/lib/system/libsystem_kernel.dylib
0xa7b74000 - 0xa7bc2fdb libsystem_m.dylib (3158.200.7) <90830E34-355E-3B80-94AF-2799DE1B2960> /usr/lib/system/libsystem_m.dylib
0xa7bc3000 - 0xa7bdffff libsystem_malloc.dylib (166.220.1) /usr/lib/system/libsystem_malloc.dylib
0xa7be0000 - 0xa7bebfff libsystem_networkextension.dylib (767.220.1) <23B154B9-AD7D-37E9-8611-A141808BFEB1> /usr/lib/system/libsystem_networkextension.dylib
0xa7bec000 - 0xa7bf2fff libsystem_notify.dylib (172.200.21) /usr/lib/system/libsystem_notify.dylib
0xa7bf3000 - 0xa7bfaffb libsystem_platform.dylib (177.200.16) <845B96BC-6B5F-32CB-A229-294BD5771435> /usr/lib/system/libsystem_platform.dylib
0xa7bfb000 - 0xa7c06ffb libsystem_pthread.dylib (330.220.2) <647CA068-5F50-3542-B101-C2F7CE3BA473> /usr/lib/system/libsystem_pthread.dylib
0xa7c07000 - 0xa7c0aff7 libsystem_sandbox.dylib (851.220.9) <5F124AC2-E305-3A26-A863-B4D0183792CC> /usr/lib/system/libsystem_sandbox.dylib
0xa7c0b000 - 0xa7c0dfff libsystem_secinit.dylib (30.220.1) <8BC61243-2315-3FA9-BC08-5B698020B293> /usr/lib/system/libsystem_secinit.dylib
0xa7c0e000 - 0xa7c15fff libsystem_symptoms.dylib (820.227.2) /usr/lib/system/libsystem_symptoms.dylib
0xa7c16000 - 0xa7c2affb libsystem_trace.dylib (906.220.1) /usr/lib/system/libsystem_trace.dylib
0xa7c2c000 - 0xa7c32fff libunwind.dylib (35.4) /usr/lib/system/libunwind.dylib
0xa7c33000 - 0xa7c62ffb libxpc.dylib (1336.220.5) <69B954DC-F4FC-3FBC-B7DC-E9CC9FE898F3> /usr/lib/system/libxpc.dylib

External Modification Summary:
Calls made by other processes targeting this process:
task_for_pid: 3
thread_create: 0
thread_set_state: 0
Calls made by this process:
task_for_pid: 0
thread_create: 0
thread_set_state: 0
Calls made by all processes on this machine:
task_for_pid: 15350
thread_create: 0
thread_set_state: 0

VM Region Summary:
ReadOnly portion of Libraries: Total=391.6M resident=0K(0%) swapped_out_or_unallocated=391.6M(100%)
Writable regions: Total=661.9M written=0K(0%) resident=0K(0%) swapped_out=0K(0%) unallocated=661.9M(100%)

VIRTUAL REGION
REGION TYPE SIZE COUNT (non-coalesced)
=========== ======= =======
Accelerate framework 128K 2
Activity Tracing 256K 2
CG backing stores 5536K 4
CG image 12K 3
CoreAnimation 124K 14
CoreGraphics 8K 2
CoreImage 16K 3
CoreUI image data 296K 6
CoreUI image file 404K 5
Foundation 4K 2
Kernel Alloc Once 8K 2
MALLOC 610.9M 102
MALLOC guard page 32K 9
Memory Tag 242 12K 2
Memory Tag 249 156K 2
OpenGL GLSL 128K 3
Stack 19.4M 16
Stack (reserved) 24.0M 2 reserved VM address space (unallocated)
Stack Guard 32.0M 14
VM_ALLOCATE 296K 25
VM_ALLOCATE (reserved) 36K 2 reserved VM address space (unallocated)
__DATA 17.7M 229
__FONT_DATA 4K 2
__GLSLBUILTINS 5176K 2
__LINKEDIT 150.7M 12
__OBJC 3188K 81
__TEXT 240.8M 231
__UNICODE 564K 2
mapped file 329.0M 216
shared memory 752K 12
=========== ======= =======
TOTAL 1.4G 979
TOTAL, minus reserved VM space 1.4G 979

Model: MacBookPro11,3, BootROM 149.0.0.0.0, 4 processors, Intel Core i7, 2.6 GHz, 16 GB, SMC 2.19f12
Graphics: Intel Iris Pro, Intel Iris Pro, Built-In
Graphics: NVIDIA GeForce GT 750M, NVIDIA GeForce GT 750M, PCIe
Memory Module: BANK 0/DIMM0, 8 GB, DDR3, 1600 MHz, 0x80AD, 0x484D54343147533641465238412D50422020
Memory Module: BANK 1/DIMM0, 8 GB, DDR3, 1600 MHz, 0x80AD, 0x484D54343147533641465238412D50422020
AirPort: spairport_wireless_card_type_airport_extreme (0x14E4, 0x134), Broadcom BCM43xx 1.0 (7.77.61.1 AirPortDriverBrcmNIC-1305.2)
Bluetooth: Version 6.0.9f2, 3 services, 27 devices, 1 incoming serial ports
Network Service: AirPort, AirPort, en0
Serial ATA Device: APPLE SSD SM1024G, 1 TB
USB Device: USB 3.0 Bus
USB Device: Apple Internal Keyboard / Trackpad
USB Device: BRCM20702 Hub
USB Device: Bluetooth USB Host Controller
Thunderbolt Bus: MacBook Pro, Apple Inc., 17.1

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OSX
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons