1595: Aflatoxin Challenge: Round 12
|Name:||1595: Aflatoxin Challenge: Round 12|
|Expired:||11/09/2018 - 23:00|
|Description:||Note: Due to a bug in solution sharing and loading, this puzzle is worth zero points and will close early. We encourage players to play replacement puzzle Puzzle 1597 instead, although we will still analyze the solutions from this puzzle if players wish to keep working on their designs. Unfortunately players may not load solutions from this puzzle into the replacement Puzzle 1597.
Redesign the active site to bind aflatoxin! This is Round 12 of the Aflatoxin Challenge. This puzzle is much like the previous round, with some active site mutations from the Siegel Lab, and players may load solutions from Round 11 into this puzzle. However, players have some more freedom in this puzzle to redesign three loops around the active site where aflatoxin binds. Players may insert up to 20 extra residues into these designable loops, at a cost of 20 points per residue. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.
Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand!
This is the twelfth puzzle of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
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