1592: Symmetric Dimer Design: Limited Interface
||1592: Symmetric Dimer Design: Limited Interface
||11/02/2018 - 23:00
||Note: Due to exceptional performance issues, this puzzle has been made worth zero points. Players should not feel compelled to play this puzzle to remain competitive on the leaderboards. However, if you are able to play this puzzle without issue, we'll still analyze any solutions.
This symmetric design puzzle has C2 symmetry, with two symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the two chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). We want to see if Foldit players can still build strong interfaces while limiting the number of nonpolar residues on the surface of each chain. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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