puzzle picture
1590c: Aflatoxin Challenge: Round 11
Status: Closed

Summary

Name: 1590c: Aflatoxin Challenge: Round 11
Status: Closed
Created: 10/24/2018
Points: 100
Expired: 11/04/2018 - 23:00
Difficulty: Intermediate
Description: Note: This puzzle replaces Puzzle 1590b, which had some intermittent scoring problems. Players may load in solutions saved from Puzzle 1590b.

Redesign the active site to bind aflatoxin! This is Round 11 of the Aflatoxin Challenge. Since the last round, the Siegel Lab has introduced a few mutations in the active site, which might allow for some new redesign. This time, we're asking players to focus on just one loop of the starting structure, which clashes with the aflatoxin ligand in the binding pocket. Players may insert up to 20 extra residues into the designable loop, at a cost of 20 points per residue. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.

Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand!

This is the eleventh puzzle of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams12,050100
2Gargleblasters12,02574
3Beta Folders12,02054
4Go Science12,00338
5Contenders11,93827

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1Phyx 76 214  12,044100
2Galaxie 2 3 Anthropic Dreams12,03698
3reefyrob 6 9 Beta Folders12,00695
4NinjaGreg 24 17 Go Science11,99092
5Blipperman 16 28 Gargleblasters11,98489


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons