puzzle picture
[DEVPREV] Aflatoxin Challenge: Round 11
Status: Closed


Name: [DEVPREV] Aflatoxin Challenge: Round 11
Status: Closed
Created: 10/17/2018
Points: 0
Expired: 11/01/2018 - 23:00
Difficulty: Intermediate
Description: Note: Due to a scoring issue, this puzzle has been moved to devprev, and will be worth zero points. Redesign the active site to bind aflatoxin! This is Round 11 of the Aflatoxin Challenge. Since the last round, the Siegel Lab has introduced a few mutations in the active site, which might allow for some new redesign. This time, we're asking players to focus on just one loop of the starting structure, which clashes with the aflatoxin ligand in the binding pocket. Players may insert up to 20 extra residues into the designable loop, at a cost of 20 points per residue. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.

Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand!

This is the eleventh puzzle of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.

Top Groups

1Beta Folders1,475,1960
2Go Science1,466,0900
3L'Alliance Francophone778,3660
4Marvin's bunch11,8110
5Anthropic Dreams11,7930

Top Evolvers

Top Soloists

1Glen B 60 2063  1,524,8700
2TastyMunchies 60 2063  1,522,4920
3LociOiling 3 1 Beta Folders1,475,1960
4Knoblerine 60 2063  1,472,2550
5fisherlr777 60 2063 Go Science1,466,0900

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NinjaGreg's picture
User offline. Last seen 2 days 23 hours ago. Offline
Joined: 05/21/2010
Groups: Go Science
Scoring is not working correctly

We now have two players with score over one million, and when running the recipe Random Idealize it appears that the unfiltered score is posted to the leaderboard, not the one after the penalty for extra segments. This is distorting the scoring.

Joined: 05/19/2009
Groups: Contenders
A score of 112.9 billion for GlenB..

Is a bit out of range. Please fix this puzzle :)

jflat06's picture
User offline. Last seen 1 hour 35 min ago. Offline
Joined: 09/29/2010
Groups: Window Group

Those are some big numbers!

We're working on figuring out what's going on here.

Does anyone have some reliable steps to reproduce this?

Joined: 02/20/2018
Groups: Go Science
Lol. My computer is dead now.

Lol. My computer is dead now. I think did bandfun and compress. I should have uploaded mine I was the first person to screw it up.

Hanto's picture
User offline. Last seen 14 weeks 6 days ago. Offline
Joined: 05/10/2008
Groups: None
1000000+ scoring

Nothing so far wrong with scoring according to y very blind eyes. A glycine Hinge on seg 13 will cause the jump.

Hanto's picture
User offline. Last seen 14 weeks 6 days ago. Offline
Joined: 05/10/2008
Groups: None

SEG 4 also having profound oositive effect using glycine hinge

Hanto's picture
User offline. Last seen 14 weeks 6 days ago. Offline
Joined: 05/10/2008
Groups: None

it APPEARS that segs 13-60 should be checked for locked status, possibly other non-active areas also.

LociOiling's picture
User offline. Last seen 35 min 25 sec ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
procedure to recreate

A good hinges recipe will do it, see the feedback: https://fold.it/portal/node/2006116

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons