[DEVPREV] Aflatoxin Challenge: Round 11

Status: Closed

Summary

Name:	[DEVPREV] Aflatoxin Challenge: Round 11
Status:	Closed
Created:	10/17/2018
Points:	0
Expired:	11/01/2018 - 23:00
Difficulty:	Intermediate
Description:	Note: Due to a scoring issue, this puzzle has been moved to devprev, and will be worth zero points. Redesign the active site to bind aflatoxin! This is Round 11 of the Aflatoxin Challenge. Since the last round, the Siegel Lab has introduced a few mutations in the active site, which might allow for some new redesign. This time, we're asking players to focus on just one loop of the starting structure, which clashes with the aflatoxin ligand in the binding pocket. Players may insert up to 20 extra residues into the designable loop, at a cost of 20 points per residue. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand! This is the eleventh puzzle of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
Categories:

Top Groups

Rank	Group	Score
1	Beta Folders	1,475,196
2	Go Science	1,466,090
3	L'Alliance Francophone	778,366
4	Marvin's bunch	11,811
5	Anthropic Dreams	11,793

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Top Evolvers

Rank	Player	Group	Score
1	Paulo Roque 83 1564	Go Science	11,368
2	Bruno Kestemont 3 4	Go Science	11,364
3	dbuske 33 182	Beta Folders	11,150
4	smilingone 14 36	Beta Folders	11,003

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Top Soloists

Rank	Player	Group	Score
1	Glen B 83 59		1,524,870
2	TastyMunchies 83 48		1,522,492
3	LociOiling 2 1	Beta Folders	1,475,196
4	Knoblerine 83 214		1,472,255
5	fisherlr777 83 641	Go Science	1,466,090

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Comments

Fri, 10/19/2018 - 03:23

NinjaGreg 21 24

Offline

Joined: 05/21/2010

Groups: Go Science

Scoring is not working correctly

We now have two players with score over one million, and when running the recipe Random Idealize it appears that the unfiltered score is posted to the leaderboard, not the one after the penalty for extra segments. This is distorting the scoring.

Fri, 10/19/2018 - 15:56

Bletchley Park 26 38

Offline

Joined: 05/19/2009

Groups: Contenders

A score of 112.9 billion for GlenB..

Is a bit out of range. Please fix this puzzle :)

Fri, 10/19/2018 - 17:15

jflat06 83 781

Offline

Joined: 09/29/2010

Groups: Window Group

Those are some big numbers!

We're working on figuring out what's going on here.

Does anyone have some reliable steps to reproduce this?

Fri, 10/19/2018 - 17:39

fisherlr777 83 641

Offline

Joined: 02/20/2018

Groups: Go Science

Lol. My computer is dead now.

Lol. My computer is dead now. I think did bandfun and compress. I should have uploaded mine I was the first person to screw it up.

Fri, 10/19/2018 - 23:01

Hanto 83 1019

Offline

Joined: 05/10/2008

Groups: None

1000000+ scoring

Nothing so far wrong with scoring according to y very blind eyes. A glycine Hinge on seg 13 will cause the jump.

Fri, 10/19/2018 - 23:34

Hanto 83 1019

Offline

Joined: 05/10/2008

Groups: None

contd

SEG 4 also having profound oositive effect using glycine hinge

Sat, 10/20/2018 - 02:37

Hanto 83 1019

Offline

Joined: 05/10/2008

Groups: None

contd

it APPEARS that segs 13-60 should be checked for locked status, possibly other non-active areas also.

Sun, 10/21/2018 - 04:49

LociOiling 2 1

Offline

Joined: 12/27/2012

Groups: Beta Folders

procedure to recreate

A good hinges recipe will do it, see the feedback: https://fold.it/portal/node/2006116

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Soloists

Evolvers

Groups

Topics

Player	Puzzle	Score
Galaxie 1 2	1683: Integrin ...d 4	9,464
LociOiling 2 1	1685: Revisitin...Fyn	10,108
johnmitch 83 9	1686: Symmetric...ues	18,451
Wulfskinner 83 229	Beginner Puzzle...ign	10,312
kribol76 83 179	Beginner Puzzle...yle	9,146
ourtown 83 134	Beginner Puzzle...zle	9,242
melbok 83 781	Beginner Puzzle...nis	9,441
kribol76 83 179	Beginner Puzzle...ity	15,935
Phyx 18 25	Beginner Puzzle...ign	13,796


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons