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1576: Large Monomer Design
Status: Closed

Summary

Name: 1576: Large Monomer Design
Status: Closed
Created: 09/20/2018
Points: 100
Expired: 09/27/2018 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 3 hours 29 min ago. Offline
Joined: 11/15/2012
Groups: None
Objectives

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +640)
Penalizes extra residues inserted beyond the starting 60 85, at a cost of 32 points per residue. Players may use up to 65 105 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.

toshiue's picture
User offline. Last seen 7 hours 21 min ago. Offline
Joined: 01/31/2016
Groups: Go Science
Resdiue Count?

It would be 85 starting, 105 maximum, and 32(?) per residue beyond 85?

bkoep's picture
User offline. Last seen 3 hours 29 min ago. Offline
Joined: 11/15/2012
Groups: None
Good catch!

I've corrected my comment above.

Joined: 03/08/2012
Groups: None
SS Design (max +500)

I got SS Design +650

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons